日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Epigenetically driven and early immune evasion in colorectal cancer evolution

表观遗传驱动和早期免疫逃逸在结直肠癌演变中的作用

Lakatos, Eszter; Gunasri, Vinaya; Zapata, Luis; Househam, Jacob; Heide, Timon; Trahearn, Nicholas; Swinyard, Ottilie; Cisneros, Luis; Lynn, Claire; Mossner, Maximilian; Kimberley, Chris; Spiteri, Inmaculada; Cresswell, George D; Llibre-Palomar, Gerard; Mitchison, Miriam; Maley, Carlo C; Jansen, Marnix; Rodriguez-Justo, Manuel; Bridgewater, John; Baker, Ann-Marie; Sottoriva, Andrea; Graham, Trevor A

Computational pathology applied to clinical colorectal cancer cohorts identifies immune and endothelial cell spatial patterns predictive of outcome

将计算病理学应用于临床结直肠癌队列,可识别预测预后的免疫细胞和内皮细胞空间分布模式。

Trahearn, Nicholas; Sakr, Chirine; Banerjee, Abhirup; Lee, Seung Hyun; Baker, Ann-Marie; Kocher, Hemant M; Angerilli, Valentina; Morano, Federica; Bergamo, Francesca; Maddalena, Giulia; Intini, Rossana; Cremolini, Chiara; Caravagna, Giulio; Graham, Trevor; Pietrantonio, Filippo; Lonardi, Sara; Fassan, Matteo; Sottoriva, Andrea

Tumor evolution metrics predict recurrence beyond 10 years in locally advanced prostate cancer

肿瘤演变指标可预测局部晚期前列腺癌10年后的复发情况

Javier Fernandez-Mateos # ,George D Cresswell # ,Nicholas Trahearn # ,Katharine Webb ,Chirine Sakr ,Andrea Lampis ,Christine Stuttle ,Catherine M Corbishley ,Vasilis Stavrinides ,Luis Zapata ,Inmaculada Spiteri ,Timon Heide ,Lewis Gallagher ,Chela James ,Daniele Ramazzotti ,Annie Gao ,Zsofia Kote-Jarai ,Ahmet Acar ,Lesley Truelove ,Paula Proszek ,Julia Murray ,Alison Reid ,Anna Wilkins ,Michael Hubank ,Ros Eeles ,David Dearnaley ,Andrea Sottoriva

Epigenome and early selection determine the tumour-immune evolutionary trajectory of colorectal cancer

表观基因组和早期选择决定了结直肠癌的肿瘤免疫进化轨迹

Lakatos, Eszter; Gunasri, Vinaya; Zapata, Luis; Househam, Jacob; Heide, Timon; Trahearn, Nicholas; Swinyard, Ottilie; Cisneros, Luis; Lynn, Claire; Mossner, Maximilian; Kimberley, Chris; Spiteri, Inmaculada; Cresswell, George D; Llibre-Palomar, Gerard; Mitchison, Miriam; Maley, Carlo C; Jansen, Marnix; Rodriguez-Justo, Manuel; Bridgewater, John; Baker, Ann-Marie; Sottoriva, Andrea; Graham, Trevor A

Regional Histopathology and Prostate MRI Positivity: A Secondary Analysis of the PROMIS Trial

区域组织病理学与前列腺MRI阳性:PROMIS试验的二次分析

Stavrinides, Vasilis; Norris, Joseph M; Karapanagiotis, Solon; Giganti, Francesco; Grey, Alistair; Trahearn, Nick; Freeman, Alex; Haider, Aiman; Carmona Echeverría, Lina María; Bott, Simon R J; Brown, Louise C; Burns-Cox, Nicholas; Dudderidge, Timothy J; El-Shater Bosaily, Ahmed; Ghei, Maneesh; Henderson, Alastair; Hindley, Richard G; Kaplan, Richard S; Oldroyd, Robert; Parker, Chris; Persad, Raj; Rosario, Derek J; Shergill, Iqbal S; Winkler, Mathias; Kirkham, Alex; Punwani, Shonit; Whitaker, Hayley C; Ahmed, Hashim U; Emberton, Mark

Quantification of spatial subclonal interactions enhancing the invasive phenotype of pediatric glioma

量化空间亚克隆相互作用增强儿童胶质瘤的侵袭性表型

Haider Tari, Ketty Kessler, Nick Trahearn, Benjamin Werner, Maria Vinci, Chris Jones, Andrea Sottoriva

Exploiting evolutionary steering to induce collateral drug sensitivity in cancer

利用进化调控诱导癌症的伴随药物敏感性

Ahmet Acar # ,Daniel Nichol # ,Javier Fernandez-Mateos ,George D Cresswell ,Iros Barozzi ,Sung Pil Hong ,Nicholas Trahearn ,Inmaculada Spiteri ,Mark Stubbs ,Rosemary Burke ,Adam Stewart ,Giulio Caravagna ,Benjamin Werner ,Georgios Vlachogiannis ,Carlo C Maley ,Luca Magnani ,Nicola Valeri ,Udai Banerji ,Andrea Sottoriva

Analysis of tumour ecological balance reveals resource-dependent adaptive strategies of ovarian cancer

肿瘤生态平衡分析揭示了卵巢癌的资源依赖型适应策略

Nawaz, Sidra; Trahearn, Nicholas A; Heindl, Andreas; Banerjee, Susana; Maley, Carlo C; Sottoriva, Andrea; Yuan, Yinyin

The Spatiotemporal Evolution of Lymph Node Spread in Early Breast Cancer

早期乳腺癌淋巴结扩散的时空演变

Peter Barry #, Alexandra Vatsiou #, Inmaculada Spiteri #, Daniel Nichol, George D Cresswell, Ahmet Acar, Nicholas Trahearn, Sarah Hrebien, Isaac Garcia-Murillas, Kate Chkhaidze, Luca Ermini, Ian Said Huntingford, Hannah Cottom, Lila Zabaglo, Konrad Koelble, Saira Khalique, Jennifer E Rusby, Francesc