日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Development of small-molecule Tau-SH3 interaction inhibitors that prevent amyloid-β toxicity and network hyperexcitability

开发预防淀粉样β蛋白毒性和网络过度兴奋的小分子 Tau-SH3 相互作用抑制剂

Jonathan R Roth, Travis Rush, Samantha J Thompson, Adam R Aldaher, Trae B Dunn, Jacob S Mesina, J Nicholas Cochran, Nicholas R Boyle, Hunter B Dean, Zhengrong Yang, Vibha Pathak, Pedro Ruiz, Mousheng Wu, Jeremy J Day, J Robert Bostwick, Mark J Suto, Corinne E Augelli-Szafran, Erik D Roberson

Alzheimer's disease risk gene BIN1 induces Tau-dependent network hyperexcitability

阿尔茨海默病风险基因 BIN1 诱导 Tau 依赖性网络过度兴奋

Yuliya Voskobiynyk #, Jonathan R Roth #, J Nicholas Cochran, Travis Rush, Nancy Vn Carullo, Jacob S Mesina, Mohammad Waqas, Rachael M Vollmer, Jeremy J Day, Lori L McMahon, Erik D Roberson

A peptide inhibitor of Tau-SH3 interactions ameliorates amyloid-β toxicity

Tau-SH3 相互作用的肽抑制剂可改善淀粉样β蛋白的毒性

Travis Rush, Jonathan R Roth, Samantha J Thompson, Adam R Aldaher, J Nicholas Cochran, Erik D Roberson

Synaptotoxicity in Alzheimer's Disease Involved a Dysregulation of Actin Cytoskeleton Dynamics through Cofilin 1 Phosphorylation

阿尔茨海默病中的突触毒性涉及通过肌动蛋白丝切蛋白 1 磷酸化导致肌动蛋白细胞骨架动力学失调

Travis Rush, Jose Martinez-Hernandez, Marc Dollmeyer, Marie Lise Frandemiche, Eve Borel, Sylvie Boisseau, Muriel Jacquier-Sarlin, Alain Buisson

The amyloid-β oligomer Aβ*56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation

淀粉样蛋白-β 寡聚体 Aβ*56 诱导神经信号的特定改变,导致 tau 磷酸化和聚集

Fatou Amar, Mathew A Sherman, Travis Rush, Megan Larson, Gabriel Boyle, Liu Chang, Jürgen Götz, Alain Buisson, Sylvain E Lesné

Rho-associated protein kinase 1 (ROCK1) is increased in Alzheimer's disease and ROCK1 depletion reduces amyloid-β levels in brain

Rho 相关蛋白激酶 1 (ROCK1) 在阿尔茨海默病中增多,ROCK1 的缺失会降低大脑中的淀粉样蛋白 β 水平

Benjamin W Henderson, Erik G Gentry, Travis Rush, Juan C Troncoso, Madhav Thambisetty, Thomas J Montine, Jeremy H Herskowitz

The Alzheimer's disease risk factor CD2AP maintains blood-brain barrier integrity

阿尔茨海默病风险因子 CD2AP 维持血脑屏障完整性

J Nicholas Cochran, Travis Rush, Susan C Buckingham, Erik D Roberson

Activity-dependent tau protein translocation to excitatory synapse is disrupted by exposure to amyloid-beta oligomers

活动依赖性 tau 蛋白易位至兴奋性突触因暴露于淀粉样β低聚物而中断

Marie Lise Frandemiche, Sandrine De Seranno, Travis Rush, Eve Borel, Auréliane Elie, Isabelle Arnal, Fabien Lanté, Alain Buisson