日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Light-Induced, Lysine-Targeting Irreversible Covalent Inhibition of the Human Oxygen Sensing Hydroxylase Factor Inhibiting HIF (FIH)

光诱导的赖氨酸靶向不可逆共价抑制人氧感应羟化酶因子HIF（FIH）

期刊:Journal of the American Chemical Society
影响因子:15.6
doi:10.1021/jacs.5c01935
Wu, Yue; Li, Zhihong; Kaur, Samanpreet; Zhang, Zewei; Yue, Jie; Tumber, Anthony; Zhang, Haoshu; Song, Zhe; Yang, Peiyao; Dong, Ying; Yang, Fulai; Li, Xiang; Schofield, Christopher J; Zhang, Xiaojin
FIH
Human
发表日期：2025
文献求助 收藏

Derivatives of the Clinically Used HIF Prolyl Hydroxylase Inhibitor Desidustat Are Efficient Inhibitors of Human γ-Butyrobetaine Hydroxylase

临床使用的HIF脯氨酰羟化酶抑制剂Desidustat的衍生物是人γ-丁酰甜菜碱羟化酶的有效抑制剂

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c00586
Corner, Thomas P; Tumber, Anthony; Salah, Eidarus; Jabbary, Mohammadparsa; Nakashima, Yu; Schnaubelt, Lara I; Basak, Shyam; Alshref, Faisal M; Brewitz, Lennart; Schofield, Christopher J
Human
发表日期：2025
文献求助 收藏

Profiling Inhibitor Scaffolds for the Cancer Target Jumonji-C Domain-Containing Protein 6

针对癌症靶点 Jumonji-C 结构域蛋白 6 的抑制剂支架分析

期刊:ChemMedChem
影响因子:3.4
doi:10.1002/cmdc.202500682
Corner, Thomas P; Salah, Eidarus; Tumber, Anthony; Holt-Martyn, James P; Brewitz, Lennart; Schofield, Christopher J
肿瘤
肿瘤免疫
发表日期：2025
文献求助 收藏

RaPID discovery of cell-permeable helical peptide inhibitors con-taining cyclic β-amino acids against SARS-CoV-2 main protease

快速发现含有环状β-氨基酸的细胞渗透性螺旋肽抑制剂，该抑制剂可抑制SARS-CoV-2主蛋白酶

期刊:RSC Chemical Biology
影响因子:3.1
doi:10.1039/d5cb00021a
Kawai, Marina; Malla, Tika R; Chan, H T Henry; Tumber, Anthony; Brewitz, Lennart; Salah, Eidarus; Terasaka, Naohiro; Katoh, Takayuki; Kawamura, Akane; Schofield, Christopher J; Duarte, Fernanda; Suga, Hiroaki
SARS-CoV-2
细胞生物学
发表日期：2025
文献求助 收藏

Biochemical investigations using mass spectrometry to monitor JMJD6-catalysed hydroxylation of multi-lysine containing bromodomain-derived substrates

利用质谱法监测JMJD6催化的多赖氨酸溴结构域衍生底物的羟基化反应的生化研究

期刊:RSC Chemical Biology
影响因子:3.1
doi:10.1039/d4cb00311j
Corner, Thomas P; Salah, Eidarus; Tumber, Anthony; Brewitz, Lennart; Schofield, Christopher J
JMJD6
发表日期：2025
文献求助 收藏

Investigating the N-terminal linker histone H1 subtypes as substrates for JmjC lysine demethylases.

研究 N 端连接组蛋白 H1 亚型作为 JmjC 赖氨酸去甲基酶的底物

期刊:RSC Chemical Biology
影响因子:3.1
doi:10.1039/d5cb00083a
Türkmen Vildan A, Tumber Anthony, Salah Eidarus, Kaur Samanpreet, Schofield Christopher J, Mecinović Jasmin
免疫/内分泌
发表日期：2025
文献求助 收藏

Substrate selectivity and inhibition of the human lysyl hydroxylase JMJD7

人赖氨酰羟化酶JMJD7的底物选择性和抑制作用

期刊:Protein Science
影响因子:5.2
doi:10.1002/pro.5162
Bilgin, Nurgül; Tumber, Anthony; Dhingra, Siddhant; Salah, Eidarus; Al-Salmy, Aziza; Martín, Sandra Pinzón; Wang, Yicheng; Schofield, Christopher J; Mecinović, Jasmin
发表日期：2024
文献求助 收藏

JmjC catalysed histone H2a N-methyl arginine demethylation and C4-arginine hydroxylation reveals importance of sequence-reactivity relationships

JmjC催化的组蛋白H2a N-甲基精氨酸去甲基化和C4-精氨酸羟基化揭示了序列反应性关系的重要性

期刊:Communications Biology
影响因子:5.1
doi:10.1038/s42003-024-07183-5
Bonnici, Joanna; Oueini, Razanne; Salah, Eidarus; Johansson, Catrine; Pires, Elisabete; Abboud, Martine; Dawber, Robert S; Tumber, Anthony; Rabe, Patrick; Saraç, Hilal; Schofield, Christopher J; Kawamura, Akane
表观遗传
发表日期：2024
文献求助 收藏

Accelerating drug target inhibitor discovery with a deep generative foundation model.

利用深度生成式基础模型加速药物靶点抑制剂的发现

期刊:Science Advances
影响因子:12.5
doi:10.1126/sciadv.adg7865
Chenthamarakshan Vijil, Hoffman Samuel C, Owen C David, Lukacik Petra, Strain-Damerell Claire, Fearon Daren, Malla Tika R, Tumber Anthony, Schofield Christopher J, Duyvesteyn Helen M E, Dejnirattisai Wanwisa, Carrique Loic, Walter Thomas S, Screaton Gavin R, Matviiuk Tetiana, Mojsilovic Aleksandra, Crain Jason, Walsh Martin A, Stuart David I, Das Payel
其它
血管生成
发表日期：2023
文献求助 收藏

Structure-guided optimisation of N-hydroxythiazole-derived inhibitors of factor inhibiting hypoxia-inducible factor-α

基于结构的N-羟基噻唑衍生物对缺氧诱导因子α抑制因子抑制剂的优化

期刊:Chemical Science
影响因子:7.4
doi:10.1039/d3sc04253g
Corner, Thomas P; Teo, Ryan Z R; Wu, Yue; Salah, Eidarus; Nakashima, Yu; Fiorini, Giorgia; Tumber, Anthony; Brasnett, Amelia; Holt-Martyn, James P; Figg, William D Jr; Zhang, Xiaojin; Brewitz, Lennart; Schofield, Christopher J
发表日期：2023
文献求助 收藏