日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Cellular senescence in liver diseases: From molecular drivers to therapeutic targeting

肝脏疾病中的细胞衰老:从分子驱动因素到治疗靶点

Du, Kuo; Umbaugh, David S; Ren, Niansheng; Diehl, Anna Mae

Zinc-dependent RNA-binding protein controls hepatocyte senescence and recovery from alcohol-related liver failure

锌依赖性RNA结合蛋白调控肝细胞衰老和酒精性肝衰竭的恢复。

Dutta, Rajesh Kumar; Du, Kuo; Ren, Niansheng; Umbaugh, David S; Oh, Seh-Hoon; Wang, Liuyang; Kalsotra, Auinash; Blackshear, Perry J; Diehl, Anna Mae

Author Correction: Targeting senescent hepatocytes for treatment of metabolic dysfunction-associated steatotic liver disease and multi-organ dysfunction

作者更正:靶向衰老肝细胞治疗代谢功能障碍相关的脂肪肝和多器官功能障碍

Du, Kuo; Umbaugh, David S; Wang, Liuyang; Jun, Ji Hye; Dutta, Rajesh K; Oh, Seh Hoon; Ren, Niansheng; Zhang, Qiaojuan; Ko, Dennis C; Ferreira, Ana; Hill, Jon; Gao, Guannan; Pullen, Steven S; Jain, Vaibhav; Gregory, Simon; Abdelmalek, Manal F; Diehl, Anna Mae

Targeting senescent hepatocytes for treatment of metabolic dysfunction-associated steatotic liver disease and multi-organ dysfunction.

靶向衰老肝细胞治疗代谢功能障碍相关的脂肪肝疾病和多器官功能障碍

Du Kuo, Umbaugh David S, Wang Liuyang, Jun Ji Hye, Dutta Rajesh K, Oh Seh Hoon, Ren Niansheng, Zhang Qiaojuan, Ko Dennis C, Ferreira Ana, Hill Jon, Gao Guannan, Pullen Steven S, Jain Vaibhav, Gregory Simon, Abdelmalek Manal F, Diehl Anna Mae

cGAS Inhibits ALDH2 to Suppress Lipid Droplet Function and Regulate MASLD Progression.

cGAS抑制ALDH2以抑制脂滴功能并调节MASLD进展。

Wang Ying, Deng Yu, Chen Jianfeng, Hahn Quentin, Umbaugh David S, Zhang Zhigang, Zhang Yanqiong, Rowe Sarah E, Li Lupeng, Herring Laura E, Conlon Brian P, Miao Edward A, Damania Blossom, Diehl Anna Mae, Liu Pengda

Redefining senescence through hepatocyte fate changes in liver diseases

通过肝细胞命运改变重新定义肝脏疾病中的衰老

Umbaugh, David S; Diehl, Anna Mae; Du, Kuo

Mixed lineage kinase domain-like protein deficiency exacerbates early injury in a mouse model of acetaminophen hepatotoxicity.

混合谱系激酶结构域样蛋白缺乏会加剧对乙酰氨基酚肝毒性小鼠模型中的早期损伤

Sanchez-Guerrero Giselle, Umbaugh David S, Smith Sawyer H, Akakpo Jephte Y, Jaeschke Hartmut, Ramachandran Anup

The chemokine CXCL14 is a novel early prognostic biomarker for poor outcome in acetaminophen-induced acute liver failure

趋化因子CXCL14是一种新型的早期预后生物标志物,可用于预测对乙酰氨基酚诱发的急性肝衰竭的不良预后。

Umbaugh, David S; Nguyen, Nga T; Curry, Steven C; Rule, Jody A; Lee, William M; Ramachandran, Anup; Jaeschke, Hartmut

Biomarker discovery in acetaminophen hepatotoxicity: leveraging single-cell transcriptomics and mechanistic insight

利用单细胞转录组学和机制解析方法发现对乙酰氨基酚肝毒性的生物标志物

Umbaugh, David S; Jaeschke, Hartmut

Regulation of Liver Regeneration by Hepatocyte O-GlcNAcylation in Mice

小鼠肝细胞O-GlcNAc糖基化对肝脏再生的调控

Robarts, Dakota R; McGreal, Steven R; Umbaugh, David S; Parkes, Wendena S; Kotulkar, Manasi; Abernathy, Sarah; Lee, Norman; Jaeschke, Hartmut; Gunewardena, Sumedha; Whelan, Stephen A; Hanover, John A; Zachara, Natasha E; Slawson, Chad; Apte, Udayan