Van Alstyne相关文献与解析，生知库 | 链接生命科学的每一步

Nuclear tau aggregates inhibit RNA export and form by secondary seeding from cytosolic tau aggregates

核内tau蛋白聚集体抑制RNA输出，并通过胞质tau蛋白聚集体的二次播种形成。

期刊:

影响因子:

doi:10.64898/2026.02.17.706203

Decker, Carolyn J; McCann, Kathleen; Lester, Evan; Pratt, James; Van Alstyne, Meaghan; Wang, Yuchen; Parker, Roy

发表日期：2026

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Polyserine domains are toxic and exacerbate tau pathology in mice

多聚丝氨酸结构域具有毒性，并会加剧小鼠的tau蛋白病理。

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:

doi:10.1073/pnas.2527425122

Van Alstyne, Meaghan; Nguyen, Vanessa L; Hoeffer, Charles A; Parker, Roy

毒理研究

发表日期：2026

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Polyserine-mediated targeting of FAF2/UBXD8 ameliorates tau aggregation

聚丝氨酸介导的FAF2/UBXD8靶向作用可改善tau蛋白聚集

期刊:Neuron

影响因子:14.7

doi:10.1016/j.neuron.2025.08.002

Meaghan Van Alstyne,Georgia Brown,Vanessa L Nguyen,Mani Ramaswami,Charles A Hoeffer,Roy Parker

TAU

发表日期：2025

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Synaptic imbalance and increased inhibition impair motor function in SMA.

SMA患者的突触失衡和抑制增强会损害运动功能

期刊:Science Advances

影响因子:12.5

doi:10.1126/sciadv.adt4126

Fletcher Emily V, Chalif Joshua I, Rotterman Travis M, Pagiazitis John G, Van Alstyne Meaghan, Sivakumar Nandhini, Florez-Paz Danny, Rabinowitz Joseph E, Pellizzoni Livio, Alvarez Francisco J, Mentis George Z

信号转导

发表日期：2025

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Identification of p38 MAPK inhibition as a neuroprotective strategy for combinatorial SMA therapy

确定 p38 MAPK 抑制作为 SMA 联合治疗的神经保护策略

期刊:EMBO Molecular Medicine

影响因子:8.3

doi:10.1038/s44321-025-00303-6

Carlini, Maria J; Espinoza-Derout, Jorge; Van Alstyne, Meaghan; Tisdale, Sarah; Workman, Eileen; Triplett, Marina K; Tattoli, Ivan; Yadav, Shubhi; Henderson, Christopher E; Watterson, D Martin; Pellizzoni, Livio

Diverse influences on tau aggregation and implications for disease progression

影响tau蛋白聚集的多种因素及其对疾病进展的影响

期刊:Genes & Development

影响因子:7.7

doi:10.1101/gad.352551.124

Van Alstyne, Meaghan; Pratt, James; Parker, Roy

发表日期：2025

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Transcriptomic analysis of iPSC-derived endothelium reveals adaptations to high altitude hypoxia in energy metabolism and inflammation

iPSC 衍生内皮细胞的转录组分析揭示了能量代谢和炎症对高原缺氧的适应性

期刊:PLoS Genetics

影响因子:

doi:10.1371/journal.pgen.1011570

Olivia A Gray, David B Witonsky, Jordan Jousma, Débora R Sobreira, Alexander Van Alstyne, Ru-Ting Huang, Yun Fang, Anna Di Rienzo

代谢

内皮细胞

Immunology/Inflammation

Nestin

发表日期：2025

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A chemical screen identifies p38 MAPK inhibition as a candidate neuroprotective strategy for combinatorial SMA therapy

化学筛选发现 p38 MAPK 抑制剂是 SMA 联合治疗的一种潜在神经保护策略。

期刊:

影响因子:

doi:10.1101/2025.03.06.641938

Carlini, Maria J; Espinoza-Derout, Jorge; Van Alstyne, Meaghan; Tisdale, Sarah; Workman, Eileen; Triplett, Marina; Tattoli, Ivan; Yadav, Shubhi; Henderson, Christopher; Watterson, Martin D; Pellizzoni, Livio

Stasimon/Tmem41b is required for cell proliferation and adult mouse survival.

Stasimon/Tmem41b 是细胞增殖和成年小鼠存活所必需的

期刊:Biochemical and Biophysical Research Communications

影响因子:2.2

doi:10.1016/j.bbrc.2024.149923

Carlini Maria J, Van Alstyne Meaghan, Yang Hua, Yadav Shubhi, Shneider Neil A, Pellizzoni Livio

Inexpensive and Reproducible 3D-Printed Mosquito Emergence Containers

低成本且可复制的3D打印蚊子羽化容器

Nuclear tau aggregates inhibit RNA export and form by secondary seeding from cytosolic tau aggregates

核内tau蛋白聚集体抑制RNA输出，并通过胞质tau蛋白聚集体的二次播种形成。

Polyserine domains are toxic and exacerbate tau pathology in mice

多聚丝氨酸结构域具有毒性，并会加剧小鼠的tau蛋白病理。

Polyserine-mediated targeting of FAF2/UBXD8 ameliorates tau aggregation

聚丝氨酸介导的FAF2/UBXD8靶向作用可改善tau蛋白聚集

Synaptic imbalance and increased inhibition impair motor function in SMA.

SMA患者的突触失衡和抑制增强会损害运动功能

Identification of p38 MAPK inhibition as a neuroprotective strategy for combinatorial SMA therapy

确定 p38 MAPK 抑制作为 SMA 联合治疗的神经保护策略

Diverse influences on tau aggregation and implications for disease progression

影响tau蛋白聚集的多种因素及其对疾病进展的影响

Transcriptomic analysis of iPSC-derived endothelium reveals adaptations to high altitude hypoxia in energy metabolism and inflammation

iPSC 衍生内皮细胞的转录组分析揭示了能量代谢和炎症对高原缺氧的适应性

A chemical screen identifies p38 MAPK inhibition as a candidate neuroprotective strategy for combinatorial SMA therapy

化学筛选发现 p38 MAPK 抑制剂是 SMA 联合治疗的一种潜在神经保护策略。

Stasimon/Tmem41b is required for cell proliferation and adult mouse survival.

Stasimon/Tmem41b 是细胞增殖和成年小鼠存活所必需的