日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction-associated steatohepatitis

肝脏脂滴胆固醇含量是代谢功能障碍相关性脂肪性肝炎的关键决定因素。

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2502978122
Sakuma, Ikki; Gaspar, Rafael C; Nasiri, Ali R; Dufour, Sylvie; Kahn, Mario; Zheng, Jie; LaMoia, Traci E; Guerra, Mateus T; Taki, Yuki; Kawashima, Yusuke; Yimlamai, Dean; Perelis, Mark; Vatner, Daniel F; Petersen, Kitt Falk; Huttasch, Maximilian; Knebel, Birgit; Kahl, Sabine; Roden, Michael; Samuel, Varman T; Tanaka, Tomoaki; Shulman, Gerald I
肝炎
代谢
发表日期：2025
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Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction-associated steatohepatitis

肝脏脂滴胆固醇含量是代谢功能障碍相关性脂肪性肝炎的关键决定因素。

期刊:
影响因子:
doi:10.1101/2025.02.25.640203
Sakuma, Ikki; Gaspar, Rafael C; Nasiri, Ali R; Dufour, Sylvie; Kahn, Mario; Zheng, Jie; LaMoia, Traci E; Guerra, Mateus T; Taki, Yuki; Kawashima, Yusuke; Yimlamai, Dean; Perelis, Mark; Vatner, Daniel F; Petersen, Kitt Falk; Huttasch, Maximilian; Knebel, Birgit; Kahl, Sabine; Roden, Michael; Samuel, Varman T; Tanaka, Tomoaki; Shulman, Gerald I
肝炎
代谢
发表日期：2025
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High-fat-diet-induced hepatic insulin resistance per se attenuates murine de novo lipogenesis

高脂饮食引起的肝脏胰岛素抵抗本身会减弱小鼠的新生脂肪生成

期刊:iScience
影响因子:4.6
doi:10.1016/j.isci.2024.111175
Leigh Goedeke, Jordan W Strober, Rebecca Suh, Lauren M Paolella, Xiruo Li, Jillian C Rogers, Max C Petersen, Ali R Nasiri, Gregori Casals, Mario Kahn, Gary W Cline, Varman T Samuel, Gerald I Shulman, Daniel F Vatner
代谢
免疫/内分泌
发表日期：2024
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Lysophosphatidic acid triggers inflammation in the liver and white adipose tissue in rat models of 1-acyl-sn-glycerol-3-phosphate acyltransferase 2 deficiency and overnutrition

溶血磷脂酸在1-酰基-sn-甘油-3-磷酸酰基转移酶2缺乏和营养过剩的大鼠模型中引发肝脏和白色脂肪组织的炎症

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2312666120
Sakuma, Ikki; Gaspar, Rafael C; Luukkonen, Panu K; Kahn, Mario; Zhang, Dongyan; Zhang, Xuchen; Murray, Sue; Golla, Jaya Prakash; Vatner, Daniel F; Samuel, Varman T; Petersen, Kitt Falk; Shulman, Gerald I
炎症/感染
炎症
Rat
发表日期：2023
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Deletion of Jazf1 gene causes early growth retardation and insulin resistance in mice

Jazf1基因缺失导致小鼠早期生长迟缓和胰岛素抵抗

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:
doi:10.1073/pnas.2213628119
Hui-Young Lee, Hye Rim Jang, Hui Li, Varman T Samuel, Karrie D Dudek, Anna B Osipovich, Mark A Magnuson, Jeffrey Sklar, Gerald I Shulman
信号转导
FCM
IF
IHC-P
WB
JAZF1
发表日期：2022
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Short-term overnutrition induces white adipose tissue insulin resistance through sn-1,2-diacylglycerol/PKCε/insulin receptor Thr1160 phosphorylation

短期营养过剩通过 sn-1,2-二酰甘油/PKCε/胰岛素受体 Thr1160 磷酸化诱导白色脂肪组织胰岛素抵抗

期刊:JCI Insight
影响因子:6.3
doi:10.1172/jci.insight.139946
Kun Lyu, Dongyan Zhang, Joongyu Song, Xiruo Li, Rachel J Perry, Varman T Samuel, Gerald I Shulman
表观遗传
WB
发表日期：2021
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A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance

膜结合二酰甘油物种诱导 PKCϵ 介导的肝脏胰岛素抵抗

期刊:Cell Metabolism
影响因子:27.7
doi:10.1016/j.cmet.2020.08.001
Kun Lyu, Ye Zhang, Dongyan Zhang, Mario Kahn, Kasper W Ter Horst, Marcos R S Rodrigues, Rafael C Gaspar, Sandro M Hirabara, Panu K Luukkonen, Seohyuk Lee, Sanjay Bhanot, Jesse Rinehart, Niels Blume, Morten Grønbech Rasch, Mireille J Serlie, Jonathan S Bogan, Gary W Cline, Varman T Samuel, Gerald I S
信号转导
Insulin Receptor
发表日期：2020
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Metabolic control analysis of hepatic glycogen synthesis in vivo

体内肝糖原合成的代谢控制分析

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:
doi:10.1073/pnas.1921694117
Yuichi Nozaki, Max C Petersen, Dongyan Zhang, Daniel F Vatner, Rachel J Perry, Abudukadier Abulizi, Sofie Haedersdal, Xian-Man Zhang, Gina M Butrico, Varman T Samuel, Graeme F Mason, Gary W Cline, Kitt F Petersen, Douglas L Rothman, Gerald I Shulman
代谢
发表日期：2020
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Ectopic lipid deposition mediates insulin resistance in adipose specific 11β-hydroxysteroid dehydrogenase type 1 transgenic mice

异位脂质沉积介导脂肪特异性11β-羟基类固醇脱氢酶1型转基因小鼠的胰岛素抵抗

期刊:Metabolism-Clinical and Experimental
影响因子:10.8
doi:10.1016/j.metabol.2018.12.003
Abudukadier Abulizi, João-Paulo Camporez, Dongyan Zhang, Varman T Samuel, Gerald I Shulman, Daniel F Vatner
信号转导
WB
Insulin Receptor
发表日期：2019
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Distinct Hepatic PKA and CDK Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production

不同的肝脏 PKA 和 CDK 信号通路控制活性独立的丙酮酸激酶磷酸化和肝脏葡萄糖生成

期刊:Cell Reports
影响因子:7.5
doi:10.1016/j.celrep.2019.11.009
Brandon M Gassaway, Rebecca L Cardone, Anil K Padyana, Max C Petersen, Evan T Judd, Sebastian Hayes, Shuilong Tong, Karl W Barber, Maria Apostolidi, Abudukadier Abulizi, Joshua B Sheetz, Kshitiz, Hans R Aerni, Stefan Gross, Charles Kung, Varman T Samuel, Gerald I Shulman, Richard G Kibbey, Jesse Rin
信号转导
表观遗传
Epigenetics
发表日期：2019
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