日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A manifesto for Alzheimer's disease drug discovery in the era of disease-modifying therapies

阿尔茨海默病药物研发在疾病修饰疗法时代的宣言

Hering, Heike; Bussiere, Thierry; Liu, Chia-Chen; Glajch, Kelly E; Weihofen, Andreas; Grogan, Jane; Walsh, Dominic M

Synaptotoxic effects of extracellular tau are mediated by its microtubule-binding region.

细胞外 tau 蛋白的突触毒性作用是由其微管结合区介导的

Ondrejcak Tomas, Hu Neng-Wei, Coode Emily, Campbell Tom, Corbett Grant T, Doykov Ivan, Mills Kevin, Walsh Dominic M, Livesey Frederick J, Rowan Michael J, Klyubin Igor

Experimental evidence that readily diffusible forms of Aβ from Alzheimer's disease brain have seeding activity.

实验证据表明,阿尔茨海默病患者大脑中易扩散的 Aβ 形式具有播种活性

Song Simin, Liu Qianmin, Chen Ruixiang, Chen Ping, Tao Min, Li Siyao, Guo Liping, Zhu Xixi, Liu Yan, Liu Lu, Sasaguri Hiroki, Saito Takashi, Saido Takaomi C, Walsh Dominic M, Zhang Zhangjin, Hong Wei

NT1-Tau Is Increased in CSF and Plasma of CJD Patients, and Correlates with Disease Progression

NT1-Tau在克雅氏病患者的脑脊液和血浆中升高,且与疾病进展相关

Mengel, David; Mok, Tze How; Nihat, Akin; Liu, Wen; Rissman, Robert A; Galasko, Douglas; Zetterberg, Henrik; Mead, Simon; Collinge, John; Walsh, Dominic M

Longitudinal plasma p-tau217 is increased in early stages of Alzheimer's disease

纵向血浆p-tau217水平在阿尔茨海默病早期阶段升高

Mattsson-Carlgren, Niklas; Janelidze, Shorena; Palmqvist, Sebastian; Cullen, Nicholas; Svenningsson, Anna L; Strandberg, Olof; Mengel, David; Walsh, Dominic M; Stomrud, Erik; Dage, Jeffrey L; Hansson, Oskar

PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins

PrP是可溶性神经退行性疾病致病蛋白聚集体介导的毒性作用的核心参与者。

Corbett, Grant T; Wang, Zemin; Hong, Wei; Colom-Cadena, Marti; Rose, Jamie; Liao, Meichen; Asfaw, Adhana; Hall, Tia C; Ding, Lai; DeSousa, Alexandra; Frosch, Matthew P; Collinge, John; Harris, David A; Perkinton, Michael S; Spires-Jones, Tara L; Young-Pearse, Tracy L; Billinton, Andrew; Walsh, Dominic M

Dynamics of plasma biomarkers in Down syndrome: the relative levels of Aβ42 decrease with age, whereas NT1 tau and NfL increase

唐氏综合征患者血浆生物标志物的动态变化:Aβ42的相对水平随年龄增长而降低,而NT1 tau和NfL的相对水平则升高。

Mengel, David; Liu, Wen; Glynn, Robert J; Selkoe, Dennis J; Strydom, Andre; Lai, Florence; Rosas, H Diana; Torres, Amy; Patsiogiannis, Vasiliki; Skotko, Brian; Walsh, Dominic M

Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer's disease

对细胞外tau蛋白复杂性的了解有助于开发基于血液的阿尔茨海默病筛查方法

Chen, Zhicheng; Mengel, David; Keshavan, Ashvini; Rissman, Robert A; Billinton, Andrew; Perkinton, Michael; Percival-Alwyn, Jennifer; Schultz, Aaron; Properzi, Michael; Johnson, Keith; Selkoe, Dennis J; Sperling, Reisa A; Patel, Purvish; Zetterberg, Henrik; Galasko, Douglas; Schott, Jonathan M; Walsh, Dominic M

Transmission of amyloid-β protein pathology from cadaveric pituitary growth hormone

尸体垂体生长激素传播淀粉样β蛋白病理

Purro, Silvia A; Farrow, Mark A; Linehan, Jacqueline; Nazari, Tamsin; Thomas, David X; Chen, Zhicheng; Mengel, David; Saito, Takashi; Saido, Takaomi; Rudge, Peter; Brandner, Sebastian; Walsh, Dominic M; Collinge, John

Extracellular Forms of Aβ and Tau from iPSC Models of Alzheimer's Disease Disrupt Synaptic Plasticity

来自阿尔茨海默病iPSC模型的细胞外Aβ和Tau蛋白会破坏突触可塑性

Hu, Neng-Wei; Corbett, Grant T; Moore, Steven; Klyubin, Igor; O'Malley, Tiernan T; Walsh, Dominic M; Livesey, Frederick J; Rowan, Michael J