日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PHD2 enzyme is an intracellular manganese sensor that initiates the homeostatic response against elevated manganese

PHD2 酶是一种细胞内锰传感器,可启动针对高锰水平的稳态反应

Kerem C Gurol, Thomas Jursa, Eun Jeong Cho, Walter Fast, Kevin N Dalby, Donald R Smith, Somshuvra Mukhopadhyay

Asymmetric dimethylarginine positively modulates calcium-sensing receptor signalling to promote lipid accumulation

不对称二甲基精氨酸积极调节钙敏感受体信号传导以促进脂质积累

Laura Dowsett, Lucie Duluc, Erin Higgins, Fatmah Alghamdi, Walter Fast, Ian P Salt, James Leiper

Carbapenem Use Is Driving the Evolution of Imipenemase 1 Variants

卡巴培南的使用正在推动亚胺培南酶 1 变体的进化

Zishuo Cheng, Christopher R Bethel, Pei W Thomas, Ben A Shurina, John-Paul Alao, Caitlyn A Thomas, Kundi Yang, Steven H Marshall, Huan Zhang, Aidan M Sturgill, Andrea N Kravats, Richard C Page, Walter Fast, Robert A Bonomo, Michael W Crowder

Iminodiacetic Acid as a Novel Metal-Binding Pharmacophore for New Delhi Metallo-β-lactamase Inhibitor Development

亚氨基二乙酸作为新德里金属-β-内酰胺酶抑制剂开发的新型金属结合药效团

Allie Y Chen, Caitlyn A Thomas, Pei W Thomas, Kundi Yang, Zishuo Cheng, Walter Fast, Michael W Crowder, Seth M Cohen

A Single Salt Bridge in VIM-20 Increases Protein Stability and Antibiotic Resistance under Low-Zinc Conditions

VIM-20 中的单盐桥可在低锌条件下提高蛋白质稳定性和抗生素耐药性

Zishuo Cheng #, Ben A Shurina #, Christopher R Bethel #, Pei W Thomas, Steven H Marshall, Caitlyn A Thomas, Kundi Yang, Robert L Kimble, Jonathan S Montgomery, Matthew G Orischak, Callie M Miller, Jordan L Tennenbaum, Jay C Nix, David L Tierney, Walter Fast, Robert A Bonomo, Richard C Page, Michael

Investigation of Dipicolinic Acid Isosteres for the Inhibition of Metallo-β-Lactamases

吡啶二羧酸等排体对金属-β-内酰胺酶抑制作用的研究

Allie Y Chen, Pei W Thomas, Zishuo Cheng, Nasa Y Xu, David L Tierney, Michael W Crowder, Walter Fast, Seth M Cohen

Evolution of New Delhi metallo-β-lactamase (NDM) in the clinic: Effects of NDM mutations on stability, zinc affinity, and mono-zinc activity

新德里金属-β-内酰胺酶 (NDM) 在临床中的演变:NDM 突变对稳定性、锌亲和力和单锌活性的影响

Zishuo Cheng, Pei W Thomas, Lincheng Ju, Alexander Bergstrom, Kelly Mason, Delaney Clayton, Callie Miller, Christopher R Bethel, Jamie VanPelt, David L Tierney, Richard C Page, Robert A Bonomo, Walter Fast, Michael W Crowder

Dissection, Optimization, and Structural Analysis of a Covalent Irreversible DDAH1 Inhibitor

共价不可逆 DDAH1 抑制剂的剖析、优化和结构分析

Gayle Burstein-Teitelbaum, Joyce A V Er, Arthur F Monzingo, Alfred Tuley, Walter Fast

Dipicolinic Acid Derivatives as Inhibitors of New Delhi Metallo-β-lactamase-1

二吡啶甲酸衍生物作为新德里金属-β-内酰胺酶-1 抑制剂

Allie Y Chen, Pei W Thomas, Alesha C Stewart, Alexander Bergstrom, Zishuo Cheng, Callie Miller, Christopher R Bethel, Steven H Marshall, Cy V Credille, Christopher L Riley, Richard C Page, Robert A Bonomo, Michael W Crowder, David L Tierney, Walter Fast, Seth M Cohen

Clinical Variants of New Delhi Metallo-β-Lactamase Are Evolving To Overcome Zinc Scarcity

新德里金属β-内酰胺酶的临床变异体正在进化以克服锌缺乏症

Alesha C Stewart,Christopher R Bethel,Jamie VanPelt,Alex Bergstrom,Zishuo Cheng,Callie G Miller,Cameron Williams,Robert Poth,Matthew Morris,Olivia Lahey,Jay C Nix,David L Tierney,Richard C Page,Michael W Crowder,Robert A Bonomo,Walter Fast