日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Potent and selective SETDB1 covalent negative allosteric modulator reduces methyltransferase activity in cells

强效且选择性的 SETDB1 共价负变构调节剂可降低细胞中的甲基转移酶活性

Mélanie Uguen, Devan J Shell, Madhushika Silva, Yu Deng, Fengling Li, Magdalena M Szewczyk, Ka Yang, Yani Zhao, Michael A Stashko, Jacqueline L Norris-Drouin, Jarod M Waybright, Serap Beldar, Justin M Rectenwald, Angie L Mordant, Thomas S Webb, Laura E Herring, Cheryl H Arrowsmith, Suzanne Ackloo, S

Sigma-2 receptor modulator CT1812 alters key pathways and rescues retinal pigment epithelium (RPE) functional deficits associated with dry age-related macular degeneration (AMD)

Sigma-2 受体调节剂 CT1812 改变关键通路并挽救与干性年龄相关性黄斑变性 (AMD) 相关的视网膜色素上皮 (RPE) 功能缺陷

Britney N Lizama #, Eloise Keeling #, Eunah Cho, Evi M Malagise, Nicole Knezovich, Lora Waybright, Emily Watto, Gary Look, Valentina Di Caro, Anthony O Caggiano, J Arjuna Ratnayaka, Mary E Hamby

Comparative analysis of KRAS4a and KRAS4b splice variants reveals distinctive structural and functional properties

KRAS4a 和 KRAS4b 剪接变体的比较分析揭示了它们独特的结构和功能特性。

Matthew J Whitley ,Timothy H Tran ,Megan Rigby ,Ming Yi ,Srisathiyanarayanan Dharmaiah ,Timothy J Waybright ,Nitya Ramakrishnan ,Shelley Perkins ,Troy Taylor ,Simon Messing ,Dominic Esposito ,Dwight V Nissley ,Frank McCormick ,Andrew G Stephen ,Thomas Turbyville ,Gabriel Cornilescu ,Dhirendra K Simanshu

Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer's disease

跨膜蛋白 97 是人类阿尔茨海默病中潜在的突触淀粉样蛋白 β 受体

Martí Colom-Cadena, Jamie Toombs, Elizabeth Simzer, Kristjan Holt, Robert McGeachan, Jane Tulloch, Rosemary J Jackson, James H Catterson, Maxwell P Spires-Jones, Jamie Rose, Lora Waybright, Anthony O Caggiano, Declan King, Francesco Gobbo, Caitlin Davies, Monique Hooley, Sophie Dunnett, Robert Tempe

Producing recombinant proteins in Vibrio natriegens

在海洋弧菌中生产重组蛋白

Smith, Matthew; Hernández, José Sánchez; Messing, Simon; Ramakrishnan, Nitya; Higgins, Brianna; Mehalko, Jennifer; Perkins, Shelley; Wall, Vanessa E; Grose, Carissa; Frank, Peter H; Cregger, Julia; Le, Phuong Vi; Johnson, Adam; Sherekar, Mukul; Pagonis, Morgan; Drew, Matt; Hong, Min; Widmeyer, Stephanie R T; Denson, John-Paul; Snead, Kelly; Poon, Ivy; Waybright, Timothy; Champagne, Allison; Esposito, Dominic; Jones, Jane; Taylor, Troy; Gillette, William

Adapting recombinant bacterial alkaline phosphatase for nucleotide exchange of small GTPases.

改造重组细菌碱性磷酸酶用于小GTP酶的核苷酸交换

Frank Peter H, Hong Min, Higgins Brianna, Perkins Shelley, Taylor Troy, Wall Vanessa E, Drew Matthew, Waybright Timothy, Gillette William, Esposito Dominic, Messing Simon

Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity

综合结构-功能分析揭示影响致癌 KRAS 活性的功能获得和丧失机制

Jason J Kwon, Julien Dilly, Shengwu Liu, Eejung Kim, Yuemin Bian, Srisathiyanarayanan Dharmaiah, Timothy H Tran, Kevin S Kapner, Seav Huong Ly, Xiaoping Yang, Dana Rabara, Timothy J Waybright, Andrew O Giacomelli, Andrew L Hong, Sean Misek, Belinda Wang, Arvind Ravi, John G Doench, Rameen Beroukhim,

Allosteric Regulation of Switch-II Domain Controls KRAS Oncogenicity

Switch-II结构域的变构调节控制KRAS致癌性

Yang, Moon Hee; Tran, Timothy H; Hunt, Bethany; Agnor, Rebecca; Johnson, Christian W; Shui, Bing; Waybright, Timothy J; Nowak, Jonathan A; Stephen, Andrew G; Simanshu, Dhirendra K; Haigis, Kevin M

A phase 1b randomized clinical trial of CT1812 to measure Aβ oligomer displacement in Alzheimer's disease using an indwelling CSF catheter

一项采用留置脑脊液导管测量阿尔茨海默病中Aβ寡聚体置换情况的CT1812 1b期随机临床试验

LaBarbera, Kelsie M; Sheline, Yvette I; Izzo, Nicholas J; Yuede, Carla M; Waybright, Lora; Yurko, Raymond; Edwards, Hannah M; Gardiner, Woodrow D; Blennow, Kaj; Zetterberg, Henrik; Börjesson-Hanson, Anne; Morgan, Roger; Davis, Charles S; Guttendorf, Robert J; Schneider, Lon S; DeKosky, Steven; LeVine, Harry 3rd; Grundman, Michael; Caggiano, Anthony O; Cirrito, John R; Catalano, Susan M; Hamby, Mary E

It is buzziness time: rearing, mating, and overwintering Bombus vosnesenskii (Hymenoptera: Apidae)

现在是蜜蜂活动最频繁的时候:饲养、交配和越冬 Bombus vosnesenskii(膜翅目:蜜蜂科)

Christman, Morgan E; Barkan, N Pinar; Campion, Claire; Heraghty, Sam D; Keaveny, Ellen C; Verble, Kelton M; Waybright, Sarah A; Dillon, Michael E; Lozier, Jeffrey D; Strange, James P