日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Expanding the toolbox to develop IAP-based degraders of TEAD transcription factors.

扩展工具箱,开发基于 IAP 的 TEAD 转录因子降解剂。

Gupta Nishma, Trainor Nicole, Radwan Mona, Nguyen Stephanie, Duncan Luke, Tang Andrew X, Beveridge Julia, Silke Natasha, Yousef Jumana, Bilgilier Ceren, Wachter Johannes, Greb Peter, Jandova Zuzana, Eliaš Ján, Kopf Sara, Gerstberger Thomas, Stolt-Bergner Peggy, Braun Nina, Weinstabl Harald, McConnell Darryl B, Mauri Federico, Lucet Isabelle S, Silke John, Chessum Nicola E A, Roy Michael J

Frustration in the protein-protein interface plays a central role in the cooperativity of PROTAC ternary complexes

蛋白质-蛋白质界面处的相互作用受阻在PROTAC三元复合物的协同作用中起着核心作用。

Ma, Ning; Bhattacharya, Supriyo; Muk, Sanychen; Jandova, Zuzana; Schmalhorst, Philipp S; Ghosh, Soumadwip; Le, Keith; Diers, Emelyne; Trainor, Nicole; Farnaby, William; Roy, Michael J; Kofink, Christiane; Greb, Peter; Weinstabl, Harald; Ciulli, Alessio; Bader, Gerd; Sankar, Kyra; Bergner, Andreas; Vaidehi, Nagarajan

Drugit: crowd-sourcing molecular design of non-peptidic VHL binders

Drugit:众包非肽类VHL结合剂的分子设计

Scott, Thomas; Smethurst, Christian Alan Paul; Westermaier, Yvonne; Mayer, Moriz; Greb, Peter; Kousek, Roland; Biberger, Tobias; Bader, Gerd; Jandova, Zuzana; Schmalhorst, Philipp S; Fuchs, Julian E; Magarkar, Aniket; Hoenke, Christoph; Gerstberger, Thomas; Combs, Steven A; Pape, Richard; Phul, Saksham; Kothiwale, Sandeepkumar; Bergner, Andreas; Waterson, Alex G; Weinstabl, Harald; McConnell, Darryl B; Meiler, Jens; Böttcher, Jark; Moretti, Rocco

At the Nexus Between Epigenetics and Senescence: The Effects of Senolytic (BI01) Administration on DNA Methylation Clock Age and the Methylome in Aged and Regenerated Skeletal Muscle.

表观遗传学与衰老之间的联系:衰老细胞清除剂 (BI01) 给药对衰老和再生骨骼肌中 DNA 甲基化时钟年龄和甲基化组的影响

Chambers Toby L, Wells Jaden, Koopmans Pieter Jan, Morena Francielly, Malik Zain B, Greene Nicholas P, Filareto Antonio, Franti Michael, Sini Patrizia, Weinstabl Harald, Brooke Robert T, Milčiūtė Milda, Gordevičius Juozas, Horvath Steve, Wen Yuan, Dungan Cory M, Murach Kevin A

Discovery and Characterization of Brigimadlin, a Novel and Highly Potent MDM2-p53 Antagonist Suitable for Intermittent Dose Schedules

发现并鉴定出一种新型高效 MDM2-p53 拮抗剂 Brigimadlin,该药适用于间歇给药方案

Andreas Gollner #, Dorothea Rudolph #, Ulrike Weyer-Czernilofsky, Rosa Baumgartinger, Peter Jung, Harald Weinstabl, Jürgen Ramharter, Rolf Grempler, Jens Quant, Jörg Rinnenthal, Alejandro Pérez Pitarch, Bojana Golubovic, Daniel Gerlach, Gerd Bader, Kristiane Wetzel, Sebastian Otto, Christian Mandl, 

Inhibition of p53-MDM2 binding reduces senescent cell abundance and improves the adaptive responses of skeletal muscle from aged mice

抑制p53-MDM2结合可减少衰老细胞数量,并改善老年小鼠骨骼肌的适应性反应。

Georgia L Nolt,Alexander R Keeble,Yuan Wen ,Aubrey C Strong,Nicholas T Thomas ,Taylor R Valentino,Camille R Brightwell ,Kevin A Murach,Sini Patrizia,Harald Weinstabl,Andreas Gollner,John J McCarthy,Christopher S Fry ,Michael Franti,Antonio Filareto,Charlotte A Peterson ,Cory M Dungan

Synthesis of Complex Tetracyclic Fused Scaffolds Enabled by (3 + 2) Cycloaddition

利用 (3 + 2) 环加成反应合成复杂的四环稠合骨架

Porte, Vincent; van Veen, Branca C; Zhang, Haoqi; Piacentini, Paolo; Matheu, Sergio Armentia; Woolford, Sophie; Sokol, Kevin R; Shaaban, Saad; Weinstabl, Harald; Maulide, Nuno

Synthesis of a (13)C-methylene-labeled isoleucine precursor as a useful tool for studying protein side-chain interactions and dynamics

合成(13)C-亚甲基标记的异亮氨酸前体作为研究蛋白质侧链相互作用和动力学的有用工具

Höfurthner, Theresa; Toscano, Giorgia; Kontaxis, Georg; Beier, Andreas; Mayer, Moriz; Geist, Leonhard; McConnell, Darryl B; Weinstabl, Harald; Lichtenecker, Roman; Konrat, Robert

BacPROTACs mediate targeted protein degradation in bacteria

BacPROTACs介导细菌中的靶向蛋白质降解

Francesca E Morreale ,Stefan Kleine ,Julia Leodolter ,Sabryna Junker ,David M Hoi ,Stepan Ovchinnikov ,Anastasia Okun ,Juliane Kley ,Robert Kurzbauer ,Lukas Junk ,Somraj Guha ,David Podlesainski ,Uli Kazmaier ,Guido Boehmelt ,Harald Weinstabl ,Klaus Rumpel ,Volker M Schmiedel ,Markus Hartl ,David Haselbach ,Anton Meinhart ,Markus Kaiser ,Tim Clausen

Electrochemical Umpolung C-H Functionalization of Oxindoles

氧吲哚的电化学极性反转CH官能化

Pastor, Miryam; Vayer, Marie; Weinstabl, Harald; Maulide, Nuno