Wellmerling相关文献与解析，生知库 | 链接生命科学的每一步

日期影响因子

Transcriptional and spatial profiling of fibroblasts from human lungs highlights CTHRC1+ cells as fibrogenic signaling hubs in fibrosis

人肺成纤维细胞的转录和空间分析表明，CTHRC1+细胞是纤维化过程中的成纤维化信号枢纽。

doi:10.64898/2026.04.08.717092

Vanegas-Avendano, N D; Chen, H; Wellmerling, J; Rodriguez-Lopez, J; Ghobashi, A; Peters, V; Sen, C; Reader, B F; Shilo, K; Gomperts, B; Ma, Q; Mora, A L; Tschumperlin, D J; Rojas, M

成纤维细胞

细胞生物学

发表日期：2026

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Myeloperoxidase promotes fibrosis by inhibiting cathepsin K to bias the lung toward ECM accumulation

髓过氧化物酶通过抑制组织蛋白酶K促进纤维化，从而使肺部倾向于细胞外基质（ECM）的积累。

doi:10.64898/2026.04.05.713467

Link, Patrick A; Wellmerling, Jack; Meridew, Jeffrey A; Naoi, Hyogo; Prakash, Y S; Rojas, Mauricio; Carmona, Eva M; Tschumperlin, Daniel J

细胞生物学

发表日期：2026

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Modulation of an aberrant basal cell program in human alveolar epithelial spheroids and lung slices

人肺泡上皮球体和肺切片中异常基底细胞程序的调控

期刊:Respiratory Research

doi:10.1186/s12931-025-03441-0

Li, Yong; Wellmerling, Jack H; Rosas, Lorena; Link, Patrick A; Chow, Daniela; Alvarez, Joshua; Choi, Kyoung M; Diaz Espinosa, Ana M; Gilbert, Rachel M; Goplen, Nicholas P; Li, Donghao; Haak, Andrew J; Prakash, Y S; Rojas, Mauricio; Tschumperlin, Daniel J

细胞生物学

发表日期：2025

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Targeting CEBPA to restore cellular identity and tissue homeostasis in pulmonary fibrosis

靶向CEBPA以恢复肺纤维化中的细胞特性和组织稳态

期刊:JCI Insight

影响因子:6.3

doi:10.1172/jci.insight.175290

Qi Tan ，Jack H Wellmerling ，Shengren Song ，Sara R Dresler ，Jeffrey A Meridew ，Kyoung M Choi ，Yong Li ，Y S Prakash ，Daniel J Tschumperlin

细胞生物学

发表日期：2024

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RNA-sequencing reveals differential fibroblast responses to bleomycin and pneumonectomy

RNA测序揭示成纤维细胞对博来霉素和肺切除术的不同反应

期刊:Physiological Reports

影响因子:2.2

doi:10.14814/phy2.16148

Jack H Wellmerling ，Sara R Dresler ，Jeffrey A Meridew ，Kyoung M Choi ，Daniel J Tschumperlin ，Qi Tan

细胞生物学

成纤维细胞

发表日期：2024

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Targeting the EGFR-ERK axis using the compatible solute ectoine to stabilize CFTR mutant F508del

使用相容性溶质四氢嘧啶 (ectoine) 靶向 EGFR-ERK 轴来稳定 CFTR 突变体 F508del

期刊:FASEB Journal

影响因子:4.4

doi:10.1096/fj.202100458RRR

Jack Wellmerling, Rachael E Rayner, Sheng-Wei Chang, Elizabeth L Kairis, Sun Hee Kim, Amit Sharma, Prosper N Boyaka, Estelle Cormet-Boyaka

发表日期：2022

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Cyclic Peptidyl Inhibitors against CAL/CFTR Interaction for Treatment of Cystic Fibrosis

针对 CAL/CFTR 相互作用的环肽基抑制剂用于治疗囊性纤维化

期刊:Journal of Medicinal Chemistry

影响因子:6.8

doi:10.1021/acs.jmedchem.0c01528

Patrick G Dougherty, Jack H Wellmerling, Amritendu Koley, Jessica K Lukowski, Amanda B Hummon, Estelle Cormet-Boyaka, Dehua Pei

发表日期：2020

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In vitro 3D culture lung model from expanded primary cystic fibrosis human airway cells

来自扩增的原代囊性纤维化人气道细胞的体外三维培养肺模型

期刊:Journal of Cystic Fibrosis

影响因子:5.4

doi:10.1016/j.jcf.2020.05.007

Rachael E Rayner, Jack Wellmerling, Wissam Osman, Sean Honesty, Maria Alfaro, Mark E Peeples, Estelle Cormet-Boyaka

细胞生物学

发表日期：2020

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Reduced expression of the Ion channel CFTR contributes to airspace enlargement as a consequence of aging and in response to cigarette smoke in mice

小鼠衰老和吸入香烟烟雾后，CFTR离子通道表达降低会导致肺泡腔扩大。

期刊:Respiratory Research

doi:10.1186/s12931-019-1170-3

Wellmerling, Jack H; Chang, Sheng-Wei; Kim, Eunsoo; Osman, Wissam H; Boyaka, Prosper N; Borchers, Michael T; Cormet-Boyaka, Estelle

发表日期：2019

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Clustering, Spatial Distribution, and Phosphorylation of Discoidin Domain Receptors 1 and 2 in Response to Soluble Collagen I

盘状结构域受体 1 和 2 在可溶性胶原蛋白 I 反应中的聚集、空间分布和磷酸化

期刊:Journal of Molecular Biology

影响因子:4.7

doi:10.1016/j.jmb.2018.11.015

David A Yeung, Nirvan Shanker, Anjum Sohail, Brent A Weiss, Carolyn Wang, Jack Wellmerling, Subhadip Das, Ramesh K Ganju, Jeanette L C Miller, Andrew B Herr, Rafael Fridman, Gunjan Agarwal

发表日期：2019

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