日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Pre-Existing Anti-Adeno-Associated Virus Immunity in Gene Therapy: Mechanisms, Challenges, and Potential Solutions

基因治疗中预先存在的抗腺相关病毒免疫:机制、挑战和潜在解决方案

Iroanya, Godwin I; Subramanyam, Pradeep N; Wells, Kevin D; Green, Jonathan A

Expression of tripartite motif family-like protein 1 and 2 in early conceptus development and placentation in the pig

猪早期胚胎发育和胎盘形成过程中三方基序家族样蛋白1和2的表达

Eitel, Emily K; Sponchiado, Mariana; Sullivan, Riley M; Lucas, Caroline G; Redel, Bethany K; Chen, Paula R; Wells, Kevin D; Prather, Randall S; Warren, Wesley C; Geisert, Rodney D

A porcine model of Fanconi anemia

范可尼贫血症的猪模型

Hergert, Brandon; Whitworth, Kristin M; Goldman, Devorah C; Moreau, Lisa; McQueen, Kelsey; Parmar, Kalindi; D'Andrea, Alan; Samuel, Melissa S; Wells, Kevin D; Prather, Randall S; Dorell, Craig; Grompe, Markus; Fleming, William H

Efficient in vivo mammalian neuron editing using peptide-mediated CRISPR enzyme delivery

利用肽介导的CRISPR酶递送实现高效的体内哺乳动物神经元编辑

Manohar, Brigette D; Travis, Meika; Munjal, Vikas; Baehr, Christopher M; Rahnama, Lily M A; Kang, Min Hyung; Haddad, Rania F; Asija, Kunica; Noel, Eric A; Peddireddy, Navya; Chouhan, Runvir S; Sharma, Rohit; Wyman, Stacia K; Krishnappa, Netravathi; Killebrew, Deirdre A; Li, Song Hua; Snow, Kathy J; Byrne, Addison K; Boosani, Chandra S; Otero, P Anthony; Bringas, John; O'Brien, Allison A; Rocco, Matthew T; Zimmerly, Madison P; Gray, Isabelle; Sran, Gunita K; Patel, Mia I; Seidensticker, Emily F; Saville, Ethan; Gaitan, Yaned; Schmelzle, Amanda L; Subramanyam, Pradeep Nag B; Samaranch, Lluis; Green, Jonathan A; Wells, Kevin D; Ehrenberg, Alexander J; Murray, Stephen A; Clelland, Claire D; Murthy, Niren; Lonser, Russell R; Hadaczek, Piotr; Van Laar, Victor S; Bankiewicz, Krystof S; Wilson, Ross C

RHO1-2 meganuclease gene editing targets human P23H rhodopsin-induced retinitis pigmentosa to rejuvenate rods and maintain cones.

RHO1-2 巨核酸酶基因编辑靶向人类 P23H 视紫红质诱导的视网膜色素变性,以恢复视杆细胞活力并维持视锥细胞功能。

Jalligampala Archana, Young Jacob M, Feist Jack, Wang Wei, Barone Francesca, Alston David C, Fransen James W, Jaikumar Gita, Kamboj Kautuk, Mooreman Caitlin, Nash Stephen, Noel Jennifer M, Pangeni Gobinda, Prestigiacomo Joseph C, Sahu Bhubanananda, Turner Caitlin, Kaplan Henry J, Green Jonathan A, Wells Kevin D, Bartsevich Victor V, Chatterton Jon E, Davis Mara, Evans Kathryn S, Lape Janel, Lewis Whitney C, van de Beek Rebecca, Viles Kristi D, Jantz Derek, Gregg Ronald G, Smith Jeff, McCall Maureen A

Amphiphilic shuttle peptide delivers base editor ribonucleoprotein to correct the CFTR R553X mutation in well-differentiated airway epithelial cells.

两亲性穿梭肽将碱基编辑器核糖核蛋白递送至分化良好的气道上皮细胞,以纠正 CFTR R553X 突变

Kulhankova Katarina, Cheng Anna X, Traore Soumba, Auger Maud, Pelletier Mia, Hervault Maxime, Wells Kevin D, Green Jonathan A, Byrne Addison, Nelson Benjamin, Sponchiado Mariana, Boosani Chandra, Heffner Caleb S, Snow Kathy J, Murray Stephen A, Villacreses Raul A, Rector Michael V, Gansemer Nicholas D, Stoltz David A, Allamargot Chantal, Couture Frédéric, Hemez Colin, Hallée Stéphanie, Barbeau Xavier, Harvey Mario, Lauvaux Coraline, Gaillet Bruno, Newby Gregory A, Liu David R, McCray Paul B Jr, Guay David

Extended survival of 9- and 10-gene-edited pig heart xenografts with ischemia minimization and CD154 costimulation blockade-based immunosuppression

通过减少缺血和基于 CD154 共刺激阻断的免疫抑制,延长了 9 个和 10 个基因编辑猪心脏异种移植的存活期

Chaban, Ryan; Ileka, Ikechukwu; McGrath, Gannon; Kinoshita, Kohei; Habibabady, Zahra; Ma, Madelyn; Diaz, Victoria; Maenaka, Akihiro; Calhoun, Anthony; Dufault, Megan; Rosales, Ivy; Laguerre, Christiana M; Sanatkar, Seyed-Amir; Burdorf, Lars; Ayares, David L; Eyestone, William; Sardana, Prachi; Kuravi, Kasinath; Sorrells, Lori; Lederman, Seth; Lucas, Caroline G; Prather, Randall S; Wells, Kevin D; Whitworth, Kristin M; Cooper, David K C; Pierson, Richard N 3rd

Oral fluid testing can be used to monitor xenotransplant donor herds for porcine cytomegalovirus/roseolovirus status

口腔液检测可用于监测异种移植供体猪群的猪巨细胞病毒/玫瑰疹病毒感染情况。

Schommer, Susan K; Samuel, Melissa S; Whitworth, Kristin M; Byrne, Addison K; Wells, Kevin D; Prather, Randall S

Profiling development of abdominal organs in the pig

猪腹部器官发育概况

Gabriel, George C; Devine, William A; Redel, Bethany K; Whitworth, Kristin M; Samuel, Melissa; Spate, Lee D; Cecil, Raissa F; Prather, Randall S; Wu, Yijen L; Wells, Kevin D; Lo, Cecilia W

Disruption of anthrax toxin receptor 1 in pigs leads to a rare disease phenotype and protection from senecavirus A infection.

猪炭疽毒素受体 1 的破坏会导致罕见的疾病表型,并能保护猪免受塞内卡病毒 A 感染

Chen Paula R, Rowland Raymond R R, Stoian Ana M, Petrovan Vlad, Sheahan Maureen, Ganta Charan, Cino-Ozuna Giselle, Kim Dae Young, Dunleavey James M, Whitworth Kristin M, Samuel Melissa S, Spate Lee D, Cecil Raissa F, Benne Joshua A, Yan Xingyu, Fang Ying, Croix Brad St, Lechtenberg Kelly, Wells Kevin D, Prather Randall S