日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Ester Prodrug NLRP3 Inflammasome Inhibitor NT-0796 is Brain Active due to Activation by Local Expression of Carboxylesterase-1

酯类前药 NLRP3 炎症小体抑制剂 NT-0796 因羧酸酯酶-1 的局部表达而被激活，从而具有脑活性。

期刊:ACS Chemical Neuroscience
影响因子:3.9
doi:10.1021/acschemneuro.5c00843
Digby, Zsofia; Diamond, Christine; Wescott, Heather; Smolak, Pam; Thornton, Peter; Lindsay, Nicola; Gabel, Christopher A; Clarke, Nicholas; Watt, Alan P
炎症
炎症/感染
神经科学
LRP3
NLRP3
炎性小体
免疫/内分泌
发表日期：2026
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Profile of NT-0527, a brain penetrant NLRP3 Inflammasome inhibitor suitable as an in vivo tool compound for neuroinflammatory disorders.

NT-0527 是一种可穿透血脑屏障的 NLRP3 炎症小体抑制剂，适用于作为神经炎症性疾病的体内治疗药物

期刊:RSC Medicinal Chemistry
影响因子:3.6
doi:10.1039/d5md00639b
Harrison David, Billinton Andy, Bock Mark G, Clarke Nicholas P, Digby Zsofia, Gabel Christopher A, Lindsay Nicola, Reader Valérie, Scanlon Jane, Smolak Pamela, Thornton Peter, Wescott Heather, Watt Alan P
神经科学
炎性小体
炎症
发表日期：2025
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Pharmacological Analysis of NLRP3 Inflammasome Inhibitor Sodium [(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl][(1-methyl-1H-pyrazol-4-yl)({[(2S)-oxolan-2-yl]methyl})sulfamoyl]azanide in Cellular and Mouse Models of Inflammation Provides a Translational Framework.

在细胞和小鼠炎症模型中对 NLRP3 炎症小体抑制剂钠 [(1,2,3,5,6,7-六氢-s-茚满-4-基)氨基甲酰基][(1-甲基-1H-吡唑-4-基)({[(2S)-氧杂环戊烷-2-基]甲基})磺酰胺酰基]氮化物进行药理学分析，为转化应用提供了框架

期刊:ACS Pharmacology and Translational Science
影响因子:3.7
doi:10.1021/acsptsci.4c00061
Doedens John R, Smolak Pamela, Nguyen MyTrang, Wescott Heather, Diamond Christine, Schooley Ken, Billinton Andy, Harrison David, Koller Beverly H, Watt Alan P, Gabel Christopher A
细胞生物学
炎性小体
Mouse
炎症
发表日期：2024
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Anthranilic amide and imidazobenzothiadiazole compounds disrupt Mycobacterium tuberculosis membrane potential

邻氨基苯甲酰胺和咪唑并苯并噻二唑类化合物会破坏结核分枝杆菌的膜电位。

期刊:Medchemcomm
影响因子:
doi:10.1039/c9md00088g
Smith, Jake; Wescott, Heather; Early, Julie; Mullen, Steven; Guzman, Junitta; Odingo, Joshua; Lamar, Jason; Parish, Tanya
发表日期：2019
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Identification of Enolase as the Target of 2-Aminothiazoles in Mycobacterium tuberculosis

结核分枝杆菌中烯醇化酶被鉴定为2-氨基噻唑类药物的作用靶点

期刊:Frontiers in Microbiology
影响因子:4.5
doi:10.3389/fmicb.2018.02542
Wescott, Heather H; Zuniga, Edison S; Bajpai, Anumita; Trujillo, Carolina; Ehrt, Sabine; Schnappinger, Dirk; Roberts, David M; Parish, Tanya
发表日期：2018
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Imidazopyridine Compounds Inhibit Mycobacterial Growth by Depleting ATP Levels

咪唑并吡啶类化合物通过消耗ATP水平抑制分枝杆菌生长

期刊:Antimicrobial Agents and Chemotherapy
影响因子:4.5
doi:10.1128/AAC.02439-17
O'Malley, Theresa; Alling, Torey; Early, Julie V; Wescott, Heather A; Kumar, Anuradha; Moraski, Garrett C; Miller, Marvin J; Masquelin, Thierry; Hipskind, Philip A; Parish, Tanya
发表日期：2018
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Imidazoles Induce Reactive Oxygen Species in Mycobacterium tuberculosis Which Is Not Associated with Cell Death

咪唑类药物可诱导结核分枝杆菌产生活性氧，但这种活性氧的产生与细胞死亡无关。

期刊:ACS Omega
影响因子:4.3
doi:10.1021/acsomega.6b00212
Howell Wescott, Heather A; Roberts, David M; Allebach, Christian L; Kokoczka, Rachel; Parish, Tanya
细胞生物学
发表日期：2017
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