Wolfe Michael S相关文献与解析，生知库 | 链接生命科学的每一步

Presenilin-1 Familial Alzheimer Mutations Impair γ-Secretase Cleavage of APP Through Stabilized Enzyme-Substrate Complex Formation

早老素-1家族性阿尔茨海默病突变通过稳定酶-底物复合物的形成损害γ-分泌酶对APP的切割

期刊:Biomolecules

影响因子:4.8

doi:10.3390/biom15070955

Devkota, Sujan; Maesako, Masato; Wolfe, Michael S

Effects of Transmembrane Phenylalanine Residues on γ-Secretase-Mediated Notch-1 Proteolysis

跨膜苯丙氨酸残基对γ-分泌酶介导的Notch-1蛋白水解的影响

期刊:ACS Chemical Neuroscience

影响因子:3.9

doi:10.1021/acschemneuro.4c00790

Malvankar, Shweta R; Wolfe, Michael S

Notch

发表日期：2025

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γ-Secretase-Mediated Endoproteolysis of Neuregulin-1 and E-Cadherin

γ-分泌酶介导的神经调节蛋白-1和E-钙黏蛋白的内切蛋白水解

期刊:Biochemistry

影响因子:3

doi:10.1021/acs.biochem.5c00095

Malvankar, Shweta R; Wolfe, Michael S

发表日期：2025

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CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 2: A NOVEL TARGET FOR THE TREATMENT OF DEMENTIAS ASSOCIATED WITH ALZHEIMER’ S DISEASE

环核苷酸磷酸二酯酶2：治疗阿尔茨海默病相关痴呆症的新靶点

期刊:

影响因子:

doi:10.1101/2025.07.16.665161

Nagarajan, Vaishnavi; Libowitz, Caitlin L; Ackley, Brian D; Wolfe, Michael S; Sidhu, Sushmita; Rahman, Tania; Krishnan, Rohan; Iqbal, Ali; Mannion, Hester; Anyim, Nnamdi; Waqas, Ahmed; Mavrogiannidis, Theodoros; Alshehabi, Ghada; Malfatto, Alessandro; Xu, *Ying

阿尔茨海默症

发表日期：2025

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Effects of presenilin-1 familial Alzheimer's disease mutations on γ-secretase activation for cleavage of amyloid precursor protein

早老素-1家族性阿尔茨海默病突变对γ-分泌酶激活切割淀粉样前体蛋白的影响

期刊:Communications Biology

影响因子:5.1

doi:10.1038/s42003-023-04539-1

Do, Hung N; Devkota, Sujan; Bhattarai, Apurba; Wolfe, Michael S; Miao, Yinglong

阿尔茨海默症

发表日期：2023

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Presenilin/γ-Secretase Activity Is Located in Acidic Compartments of Live Neurons

早老素/γ-分泌酶活性位于活神经元的酸性区室中

期刊:Journal of Neuroscience

影响因子:4

doi:10.1523/JNEUROSCI.1698-21.2021

Maesako, Masato; Houser, Mei C Q; Turchyna, Yuliia; Wolfe, Michael S; Berezovska, Oksana

神经科学

发表日期：2022

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Kinetics of the multitasking high-affinity Win binding site of WDR5 in restricted and unrestricted conditions

在限制和非限制条件下 WDR5 多任务高亲和力 Win 结合位点的动力学

期刊:Biochemical Journal

影响因子:4.4

doi:10.1042/BCJ20210253

Ali Imran, Brandon S Moyer, Ashley J Canning, Dan Kalina, Thomas M Duncan, Kelsey J Moody, Aaron J Wolfe, Michael S Cosgrove, Liviu Movileanu

信号转导

发表日期：2021

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Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate Î³-secretase function in generating Alzheimer-causing AÎ² peptides.

早老素-1 的亲水环 1 和 APP GxxxG 跨膜基序调节 α³-分泌酶功能，从而生成导致阿尔茨海默病的 Aβ 肽

期刊:Journal of Biological Chemistry

影响因子:3.9

doi:10.1016/j.jbc.2021.100393

Liu Lei, Lauro Bianca M, Wolfe Michael S, Selkoe Dennis J

Mutations in the Amyloid-β Protein Precursor Reduce Mitochondrial Function and Alter Gene Expression Independent of 42-Residue Amyloid-β Peptide

淀粉样β蛋白前体突变会降低线粒体功能并改变基因表达，而与42个氨基酸残基的淀粉样β肽无关。

期刊:Journal of Alzheimers Disease

影响因子:3.1

doi:10.3233/JAD-210366

Pope, Chad A; Wilkins, Heather M; Swerdlow, Russell H; Wolfe, Michael S

线粒体

发表日期：2021

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Alzheimer-mutant γ-secretase complexes stall amyloid β-peptide production

阿尔茨海默病突变型γ-分泌酶复合物会阻碍淀粉样β肽的生成。

Presenilin-1 Familial Alzheimer Mutations Impair γ-Secretase Cleavage of APP Through Stabilized Enzyme-Substrate Complex Formation

早老素-1家族性阿尔茨海默病突变通过稳定酶-底物复合物的形成损害γ-分泌酶对APP的切割

Effects of Transmembrane Phenylalanine Residues on γ-Secretase-Mediated Notch-1 Proteolysis

跨膜苯丙氨酸残基对γ-分泌酶介导的Notch-1蛋白水解的影响

γ-Secretase-Mediated Endoproteolysis of Neuregulin-1 and E-Cadherin

γ-分泌酶介导的神经调节蛋白-1和E-钙黏蛋白的内切蛋白水解

CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 2: A NOVEL TARGET FOR THE TREATMENT OF DEMENTIAS ASSOCIATED WITH ALZHEIMER’ S DISEASE

环核苷酸磷酸二酯酶2：治疗阿尔茨海默病相关痴呆症的新靶点

Effects of presenilin-1 familial Alzheimer's disease mutations on γ-secretase activation for cleavage of amyloid precursor protein

早老素-1家族性阿尔茨海默病突变对γ-分泌酶激活切割淀粉样前体蛋白的影响

Presenilin/γ-Secretase Activity Is Located in Acidic Compartments of Live Neurons

早老素/γ-分泌酶活性位于活神经元的酸性区室中

Kinetics of the multitasking high-affinity Win binding site of WDR5 in restricted and unrestricted conditions

在限制和非限制条件下 WDR5 多任务高亲和力 Win 结合位点的动力学

Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate Î³-secretase function in generating Alzheimer-causing AÎ² peptides.

早老素-1 的亲水环 1 和 APP GxxxG 跨膜基序调节 α³-分泌酶功能，从而生成导致阿尔茨海默病的 Aβ 肽

Mutations in the Amyloid-β Protein Precursor Reduce Mitochondrial Function and Alter Gene Expression Independent of 42-Residue Amyloid-β Peptide

淀粉样β蛋白前体突变会降低线粒体功能并改变基因表达，而与42个氨基酸残基的淀粉样β肽无关。