In Colorectal Cancer Cells With Mutant KRAS, SLC25A22-Mediated Glutaminolysis Reduces DNA Demethylation to Increase WNT Signaling, Stemness, and Drug Resistance
在具有突变 KRAS 的结肠直肠癌细胞中,SLC25A22 介导的谷氨酰胺分解可降低 DNA 去甲基化,从而增强 WNT 信号传导、干细胞特性和耐药性
期刊:Gastroenterology
影响因子:25.7
doi:10.1053/j.gastro.2020.08.016
Chi Chun Wong, Jiaying Xu, Xiqing Bian, Jian-Lin Wu, Wei Kang, Yun Qian, Weilin Li, Huarong Chen, Hongyan Gou, Dabin Liu, Simson Tsz Yat Luk, Qiming Zhou, Fenfen Ji, Lam-Shing Chan, Senji Shirasawa, Joseph Jy Sung, Jun Yu
信号转导
发育与干细胞
肿瘤
肠癌
干细胞
Wnt/β-Catenin