日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Optimizing drug design by merging generative AI with a physics-based active learning framework.

将生成式人工智能与基于物理的主动学习框架相结合,优化药物设计

Filella-Merce Isaac, Molina Alexis, Díaz Lucía, Orzechowski Marek, Berchiche Yamina A, Zhu Yang Ming, Vilalta-Mor Júlia, Malo Laura, Yekkirala Ajay S, Ray Soumya, Guallar Victor

Bortezomib-induced neuropathy is in part mediated by the sensitization of TRPV1 channels.

硼替佐米引起的神经病变部分是由 TRPV1 通道的敏化介导的

Sprague Jared M, Yekkirala Ajay S, Singh Bhagat, Tochitsky Ivan, Stephens Michael, Viramontes Octavio, Ivanis Jelena, Biscola Natalia P, Havton Leif A, Woolf Clifford J, Latremoliere Alban

Basic/Translational Development of Forthcoming Opioid- and Nonopioid-Targeted Pain Therapeutics

即将推出的阿片类和非阿片类靶向镇痛疗法的基础/转化开发

Knezevic, Nebojsa Nick; Yekkirala, Ajay; Yaksh, Tony L

A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program

周围神经固有轴突生长程序的系统级分析

Chandran, Vijayendran; Coppola, Giovanni; Nawabi, Homaira; Omura, Takao; Versano, Revital; Huebner, Eric A; Zhang, Alice; Costigan, Michael; Yekkirala, Ajay; Barrett, Lee; Blesch, Armin; Michaelevski, Izhak; Davis-Turak, Jeremy; Gao, Fuying; Langfelder, Peter; Horvath, Steve; He, Zhigang; Benowitz, Larry; Fainzilber, Mike; Tuszynski, Mark; Woolf, Clifford J; Geschwind, Daniel H

Bivalent ligands that target μ opioid (MOP) and cannabinoid1 (CB1) receptors are potent analgesics devoid of tolerance.

靶向α阿片受体(MOP)和大麻素1受体(CB1)的二价配体是强效镇痛药,且无耐受性

Le Naour Morgan, Akgün Eyup, Yekkirala Ajay, Lunzer Mary M, Powers Mike D, Kalyuzhny Alexander E, Portoghese Philip S

An immunocytochemical-derived correlate for evaluating the bridging of heteromeric mu-delta opioid protomers by bivalent ligands

一种基于免疫细胞化学的相关性分析方法,用于评估二价配体对异源μ-δ阿片受体原体的桥接作用

Yekkirala, Ajay S; Kalyuzhny, Alexander E; Portoghese, Philip S

Clinically employed opioid analgesics produce antinociception via μ-δ opioid receptor heteromers in Rhesus monkeys

临床上使用的阿片类镇痛药通过恒河猴体内的μ-δ阿片受体异聚体产生镇痛作用。

Yekkirala, Ajay S; Banks, Matthew L; Lunzer, Mary M; Negus, Stevens S; Rice, Kenner C; Portoghese, Philip S

A bivalent ligand (KMN-21) antagonist for mu/kappa heterodimeric opioid receptors

μ/κ异二聚体阿片受体的二价配体(KMN-21)拮抗剂

Zhang, Shijun; Yekkirala, Ajay; Tang, Ye; Portoghese, Philip S

Naloxone acts as a potent analgesic in transgenic mouse models of sickle cell anemia.

纳洛酮在镰状细胞贫血转基因小鼠模型中具有强效镇痛作用

Lunzer Mary M, Yekkirala Ajay, Hebbel Robert P, Portoghese Philip S