日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Alkyne Two-Phase Strategy: Rapid Generation of TK-285-Derived PROTACs as BRD4 Degraders

炔烃两相策略：快速生成TK-285衍生的PROTACs作为BRD4降解剂

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c03771
Yamakoshi, Hiroyuki; Watanabe, Ryo; Segawa, Ryosuke; Ishihara, Ryosuke; Tachibana, Ryo; Kudo, Genki; Nagasawa, Shota; Yamanaka, Satoshi; Ito, Ayano; Takeda, Hiroyuki; Sawasaki, Tatsuya; Yoshino, Ryunosuke; Hirokawa, Takatsugu; Doi, Takayuki; Hirasawa, Noriyasu; Iwabuchi, Yoshiharu
BRD4
发表日期：2026
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CrypToth: Cryptic Pocket Detection through Mixed-Solvent Molecular Dynamics Simulations-Based Topological Data Analysis

CrypToth：基于混合溶剂分子动力学模拟的拓扑数据分析的隐蔽口袋检测

期刊:Journal of Chemical Information and Modeling
影响因子:5.3
doi:10.1021/acs.jcim.4c02111
Koseki, Jun; Motono, Chie; Yanagisawa, Keisuke; Kudo, Genki; Yoshino, Ryunosuke; Hirokawa, Takatsugu; Imai, Kenichiro
发表日期：2025
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Construction of PROTAC-Mediated Ternary Complex Structure Distribution Profiles Using Extensive Conformational Search

利用广泛的构象搜索构建PROTAC介导的三元复合物结构分布图

期刊:Journal of Chemical Information and Modeling
影响因子:5.3
doi:10.1021/acs.jcim.5c00102
Kudo, Genki; Hirao, Takumi; Harada, Ryuhei; Shigeta, Yasuteru; Hirokawa, Takatsugu; Yoshino, Ryunosuke
发表日期：2025
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Molecular simulation-based 3D structural construction of olfactory receptor with agonist binding

基于分子模拟的嗅觉受体及其激动剂结合的三维结构构建

期刊:Journal of Computer-Aided Molecular Design
影响因子:3.1
doi:10.1007/s10822-025-00706-0
Hirao, Takumi; Ihara, Yusuke; Ijichi, Chiori; Kudo, Genki; Yoshino, Ryunosuke; Hirokawa, Takatsugu
信号转导
发表日期：2025
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Effects of chemosynthetic choline plasmalogens on gonadotropin secretion from bovine gonadotrophs.

化学合成胆碱缩醛磷脂对牛促性腺激素细胞促性腺激素分泌的影响

期刊:Journal of Reproduction and Development
影响因子:2.2
doi:10.1262/jrd.2025-019
Kadokawa Hiroya, Niyonzima Yvan Bienvenu, Hirokawa Takatsugu, Yoshino Ryunosuke
细胞生物学
Bovine
发表日期：2025
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Site Identification and Next Choice Protocol for Hit-to-Lead Optimization

靶点识别和后续选择方案在命中到潜在客户优化中的应用

期刊:Journal of Chemical Information and Modeling
影响因子:5.3
doi:10.1021/acs.jcim.3c02036
Kudo, Genki; Hirao, Takumi; Yoshino, Ryunosuke; Shigeta, Yasuteru; Hirokawa, Takatsugu
发表日期：2024
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Prediction of the binding mechanism of a selective DNA methyltransferase 3A inhibitor by molecular simulation

利用分子模拟预测选择性DNA甲基转移酶3A抑制剂的结合机制

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-024-64236-9
Kudo, Genki; Hirao, Takumi; Harada, Ryuhei; Hirokawa, Takatsugu; Shigeta, Yasuteru; Yoshino, Ryunosuke
发表日期：2024
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AAp-MSMD: Amino Acid Preference Mapping on Protein-Protein Interaction Surfaces Using Mixed-Solvent Molecular Dynamics

AAp-MSMD：利用混合溶剂分子动力学方法绘制蛋白质-蛋白质相互作用表面上的氨基酸偏好图

期刊:Journal of Chemical Information and Modeling
影响因子:5.3
doi:10.1021/acs.jcim.3c01677
Kudo, Genki; Yanagisawa, Keisuke; Yoshino, Ryunosuke; Hirokawa, Takatsugu
多发性硬化症
发表日期：2023
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Discovery of a Hidden Trypanosoma cruzi Spermidine Synthase Binding Site and Inhibitors through In Silico, In Vitro, and X-ray Crystallography

通过计算机模拟、体外实验和X射线晶体学方法发现克氏锥虫亚精胺合酶的隐藏结合位点及其抑制剂

期刊:ACS Omega
影响因子:4.3
doi:10.1021/acsomega.3c01314
Yoshino, Ryunosuke; Yasuo, Nobuaki; Hagiwara, Yohsuke; Ishida, Takashi; Inaoka, Daniel Ken; Amano, Yasushi; Tateishi, Yukihiro; Ohno, Kazuki; Namatame, Ichiji; Niimi, Tatsuya; Orita, Masaya; Kita, Kiyoshi; Akiyama, Yutaka; Sekijima, Masakazu
发表日期：2023
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Non-steroidal inhibitors of Drosophila melanogaster steroidogenic glutathione S-transferase Noppera-bo

果蝇类固醇生成谷胱甘肽S-转移酶的非甾体抑制剂 Noppera-bo

期刊:Journal of Pesticide Science
影响因子:1.8
doi:10.1584/jpestics.D20-072
Koiwai, Kotaro; Morohashi, Kana; Inaba, Kazue; Ebihara, Kana; Kojima, Hirotatsu; Okabe, Takayoshi; Yoshino, Ryunosuke; Hirokawa, Takatsugu; Nampo, Taiki; Fujikawa, Yuuta; Inoue, Hideshi; Yumoto, Fumiaki; Senda, Toshiya; Niwa, Ryusuke
Drosophila
发表日期：2021
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