Tamsulosin ameliorates bone loss by inhibiting the release of Cl(-) through wedging into an allosteric site of TMEM16A
坦索罗辛通过楔入TMEM16A的变构位点抑制Cl(-)的释放,从而改善骨质流失。
期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2407493121
Li, Shiliang; Sun, Weijia; Li, Shuang; Zhu, Lili; Guo, Shuai; He, Jiaqi; Li, Yuheng; Tian, Chaoquan; Zhao, Zhenjiang; Yu, Tao; Li, Jianwei; Zhang, Yiqing; Hai, Youlong; Wang, Jiawen; Zheng, Yongjun; Wang, Rui; Hu, Xiaoyong; Ling, Shukuan; Li, Honglin; Li, Yingxian