日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of a Potent and Selective Protein Arginine Methyltransferase 5 (PRMT5) PROTAC Degrader.

发现一种高效且选择性的蛋白质精氨酸甲基转移酶 5 (PRMT5) PROTAC 降解剂

Zhong Yue, Kim Huensuk, Qian Chao, Xie Ling, Chen Xian, Xiong Yan, Hu Jacqueline, Chen Matthew, Guccione Ernesto, Shen Yudao, Jin Jian

Epigenomic analysis identifies DTP subpopulation using HOPX to develop targeted therapy resistance in lung adenocarcinoma.

利用 HOPX 进行表观基因组分析,识别 DTP 亚群,从而在肺腺癌中产生靶向治疗耐药性

Tian Yang, Bhattacharya Reshmee, Yoo Seungyeul, Jiang Feng, Park Eric, Lara Granados Genesis, Shen Yudao, Park Kwang-Su, Kaniskan Husnu Umit, Jin Jian, Hopkins Benjamin D, Zhu Jun, Watanabe Hideo

Dissecting and targeting noncanonical functions of EZH2 in multiple myeloma via an EZH2 degrader

通过 EZH2 降解剂剖析和靶向多发性骨髓瘤中 EZH2 的非规范功能

Xufen Yu #, Jun Wang #, Weida Gong, Anqi Ma, Yudao Shen, Chengwei Zhang, Xijuan Liu, Ling Cai, Jing Liu, Gang Greg Wang, Jian Jin

EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis

EZH2 通过一个隐蔽的转录激活结构域以非经典方式结合 cMyc 和 p300,从而介导基因激活并促进肿瘤发生。

Jun Wang # ,Xufen Yu # ,Weida Gong ,Xijuan Liu ,Kwang-Su Park ,Anqi Ma ,Yi-Hsuan Tsai ,Yudao Shen ,Takashi Onikubo ,Wen-Chieh Pi ,David F Allison ,Jing Liu ,Wei-Yi Chen ,Ling Cai ,Robert G Roeder ,Jian Jin ,Gang Greg Wang

PRMT inhibition induces a viral mimicry response in triple-negative breast cancer

PRMT 抑制可诱导三阴性乳腺癌的病毒模拟反应

Qin Wu #, David Y Nie #, Wail Ba-Alawi, YiShuai Ji, ZiWen Zhang, Jennifer Cruickshank, Jillian Haight, Felipe E Ciamponi, Jocelyn Chen, Shili Duan, Yudao Shen, Jing Liu, Sajid A Marhon, Parinaz Mehdipour, Magdalena M Szewczyk, Nergiz Dogan-Artun, WenJun Chen, Lan Xin Zhang, Genevieve Deblois, Panagi

Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic

发现一种双重WDR5和Ikaros PROTAC降解剂作为抗癌疗法

Li, Dongxu; Yu, Xufen; Kottur, Jithesh; Gong, Weida; Zhang, Zhao; Storey, Aaron J; Tsai, Yi-Hsuan; Uryu, Hidetaka; Shen, Yudao; Byrum, Stephanie D; Edmondson, Rick D; Mackintosh, Samuel G; Cai, Ling; Liu, Zhijie; Aggarwal, Aneel K; Tackett, Alan J; Liu, Jing; Jin, Jian; Wang, Gang Greg

Exploring Degradation of Mutant and Wild-Type Epidermal Growth Factor Receptors Induced by Proteolysis-Targeting Chimeras

探索蛋白水解靶向嵌合体诱导的突变型和野生型表皮生长因子受体的降解

Xufen Yu, Meng Cheng, Kaylene Lu, Yudao Shen, Yue Zhong, Jing Liu, Yue Xiong, Jian Jin

Discovery of Potent, Selective, and In Vivo Efficacious AKT Kinase Protein Degraders via Structure-Activity Relationship Studies

通过构效关系研究发现强效、选择性且体内有效的 AKT 激酶蛋白降解剂

Xufen Yu, Jia Xu, Yudao Shen, Kaitlyn M Cahuzac, Kwang-Su Park, Brandon Dale, Jing Liu, Ramon E Parsons, Jian Jin

Novel Allosteric Inhibitor-Derived AKT Proteolysis Targeting Chimeras (PROTACs) Enable Potent and Selective AKT Degradation in KRAS/BRAF Mutant Cells

新型变构抑制剂衍生的 AKT 蛋白水解靶向嵌合体 (PROTAC) 可在 KRAS/BRAF 突变细胞中实现强效且选择性的 AKT 降解

Xufen Yu, Jia Xu, Kaitlyn M Cahuzac, Ling Xie, Yudao Shen, Xian Chen, Jing Liu, Ramon E Parsons, Jian Jin

Targeting Triple-Negative Breast Cancer by a Novel Proteolysis Targeting Chimera Degrader of Enhancer of Zeste Homolog 2

通过新型蛋白水解靶向 Zeste 同源物 2 增强子的嵌合体降解剂来靶向三阴性乳腺癌

Brandon Dale, Chris Anderson, Kwang-Su Park, H Ümit Kaniskan, Anqi Ma, Yudao Shen, Chengwei Zhang, Ling Xie, Xian Chen, Xufen Yu, Jian Jin