日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Docking for EP4R antagonists active against inflammatory pain

针对炎症疼痛的 EP4R 拮抗剂对接

Stefan Gahbauer #, Chelsea DeLeon #, Joao M Braz #, Veronica Craik, Hye Jin Kang, Xiaobo Wan, Xi-Ping Huang, Christian B Billesbølle, Yongfeng Liu, Tao Che, Ishan Deshpande, Madison Jewell, Elissa A Fink, Ivan S Kondratov, Yurii S Moroz, John J Irwin, Allan I Basbaum, Bryan L Roth, Brian K Shoichet4

Structure-Based Discovery of Inhibitors of the SARS-CoV-2 Nsp14 N7-Methyltransferase

基于结构的 SARS-CoV-2 Nsp14 N7-甲基转移酶抑制剂发现

Isha Singh, Fengling Li, Elissa A Fink, Irene Chau, Alice Li, Annía Rodriguez-Hernández, Isabella Glenn, Francisco J Zapatero-Belinchón, M Luis Rodriguez, Kanchan Devkota, Zhijie Deng, Kris White, Xiaobo Wan, Nataliya A Tolmachova, Yurii S Moroz, H Ümit Kaniskan, Melanie Ott, Adolfo García-Sastre, J

Structure-based discovery of nonopioid analgesics acting through the α2A-adrenergic receptor

基于结构的发现通过 α2A 肾上腺素受体起作用的非阿片类镇痛药

Elissa A Fink #, Jun Xu #, Harald Hübner #, Joao M Braz #, Philipp Seemann #, Charlotte Avet, Veronica Craik, Dorothee Weikert, Maximilian F Schmidt, Chase M Webb, Nataliya A Tolmachova, Yurii S Moroz, Xi-Ping Huang, Chakrapani Kalyanaraman, Stefan Gahbauer, Geng Chen, Zheng Liu, Matthew P Jacobson,

Structures of the σ2 receptor enable docking for bioactive ligand discovery

σ2 受体的结构有助于对接以发现生物活性配体

Assaf Alon #, Jiankun Lyu #, Joao M Braz #, Tia A Tummino, Veronica Craik, Matthew J O'Meara, Chase M Webb, Dmytro S Radchenko, Yurii S Moroz, Xi-Ping Huang, Yongfeng Liu, Bryan L Roth, John J Irwin, Allan I Basbaum, Brian K Shoichet, Andrew C Kruse

Virtual discovery of melatonin receptor ligands to modulate circadian rhythms

虚拟发现褪黑激素受体配体来调节昼夜节律

Reed M Stein #, Hye Jin Kang #, John D McCorvy #, Grant C Glatfelter #, Anthony J Jones, Tao Che, Samuel Slocum, Xi-Ping Huang, Olena Savych, Yurii S Moroz, Benjamin Stauch, Linda C Johansson, Vadim Cherezov, Terry Kenakin, John J Irwin, Brian K Shoichet, Bryan L Roth, Margarita L Dubocovich3

SAR by Space: Enriching Hit Sets from the Chemical Space

空间 SAR:从化学空间丰富命中集

Franca-Maria Klingler, Marcus Gastreich, Oleksandr O Grygorenko, Olena Savych, Petro Borysko, Anastasia Griniukova, Kateryna E Gubina, Christian Lemmen, Yurii S Moroz

Short peptides self-assemble to produce catalytic amyloids

短肽自组装形成催化性淀粉样蛋白

Rufo, Caroline M; Moroz, Yurii S; Moroz, Olesia V; Stöhr, Jan; Smith, Tyler A; Hu, Xiaozhen; DeGrado, William F; Korendovych, Ivan V

Painting proteins blue: β-(1-azulenyl)-L-alanine as a probe for studying protein-protein interactions

将蛋白质染成蓝色:β-(1-azulenyl)-L-丙氨酸作为研究蛋白质-蛋白质相互作用的探针

Yurii S Moroz, Wolfgang Binder, Patrik Nygren, Gregory A Caputo, Ivan V Korendovych