日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

An active metabolite of the anti-COVID-19 drug molnupiravir impairs mouse preimplantation embryos at clinically relevant concentrations

抗 COVID-19 药物莫努匹韦的活性代谢物在临床相关浓度下会损害小鼠植入前胚胎

Yusuke Marikawa, Vernadeth B Alarcon

Developmental toxicity of remdesivir, an anti-COVID-19 drug, is implicated by in vitro assays using morphogenetic embryoid bodies of mouse and human pluripotent stem cells

使用小鼠和人类多能干细胞的形态发生胚状体进行的体外试验表明,抗 COVID-19 药物瑞德西韦具有发育毒性

Lauren Kirkwood-Johnson, Yusuke Marikawa

Remdesivir impairs mouse preimplantation embryo development at therapeutic concentrations

瑞德西韦在治疗浓度下会损害小鼠植入前胚胎的发育

Yusuke Marikawa, Vernadeth B Alarcon

Regulation of endoplasmic reticulum stress and trophectoderm lineage specification by the mevalonate pathway in the mouse preimplantation embryo

小鼠植入前胚胎中甲羟戊酸途径对内质网应激和滋养外胚层谱系特征的调节

Yusuke Marikawa, Mark Menor, Youping Deng, Vernadeth B Alarcon

Dolutegravir Impairs Stem Cell-Based 3D Morphogenesis Models in a Manner Dependent on Dose and Timing of Exposure: An Implication for Its Developmental Toxicity

多替拉韦以依赖于剂量和暴露时间的方式损害基于干细胞的 3D 形态发生模型:对其发育毒性的影响

Lauren Kirkwood-Johnson, Nana Katayama, Yusuke Marikawa

Exposure-based assessment of chemical teratogenicity using morphogenetic aggregates of human embryonic stem cells

使用人类胚胎干细胞形态发生聚集体进行基于暴露的化学致畸性评估

Yusuke Marikawa, Hong-Ru Chen, Mark Menor, Youping Deng, Vernadeth B Alarcon

Methoxyacetic acid inhibits histone deacetylase and impairs axial elongation morphogenesis of mouse gastruloids in a retinoic acid signaling-dependent manner

甲氧基乙酸以视黄酸信号依赖的方式抑制组蛋白去乙酰化酶并损害小鼠原肠胚的轴向伸长形态发生

Aileen S W Li, Yusuke Marikawa

RHOA activity in expanding blastocysts is essential to regulate HIPPO-YAP signaling and to maintain the trophectoderm-specific gene expression program in a ROCK/actin filament-independent manner

正在扩增的囊胚中的 RHOA 活性对于调节 HIPPO-YAP 信号传导和以 ROCK/肌动蛋白丝非依赖的方式维持滋养外胚层特异性基因表达程序至关重要

Yusuke Marikawa, Vernadeth B Alarcon

Fluoxetine Inhibits Canonical Wnt Signaling to Impair Embryoid Body Morphogenesis: Potential Teratogenic Mechanisms of a Commonly Used Antidepressant

氟西汀抑制典型 Wnt 信号传导以损害胚状体形态发生:常用抗抑郁药的潜在致畸机制

Erica L L Warkus, Yusuke Marikawa

Embryoid body test with morphological and molecular endpoints implicates potential developmental toxicity of trans-resveratrol

具有形态学和分子终点的胚状体测试表明反式白藜芦醇具有潜在的发育毒性

Iris Q Kim, Yusuke Marikawa