文献库，生知库 | 链接生命科学的每一步

日期影响因子

Hexahydroquinoline Featuring Amide Functionality: A Promising Scaffold With Calcium Channel Blocking Activity

具有酰胺官能团的六氢喹啉：一种具有钙通道阻断活性的潜在骨架

期刊:Drug Development Research

影响因子:4.2

doi:10.1002/ddr.70261

Koçak Aslan, Ebru; Lam, Kevin; Huang, Sun; Coşkun, Göknil Pelin; Karagüzel, Ayşe; Denzinger, Katrin; Birgül, Kaan; Ülgen, Mert; Nafie, Jordan W; Şahin, Onur; Armstrong, Daniel W; Zamponi, Gerald W; Wolber, Gerhard; Gündüz, Miyase Gözde

发表日期：2026

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N-terminal Î±-amino SUMOylation promotes phosphorylation-independent cofilin-1 translocation to the mitochondrial matrix and induces apoptosis.

N 端 α-氨基 SUMO 化促进不依赖于磷酸化的 cofilin-1 易位至线粒体基质，并诱导细胞凋亡。

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-025-66859-6

Deng Qi, Gu Xiaokun, Feng Jiaqian, Xiang Jinhua, Li Xinyue, Weng Weiji, Zamponi Gerald W, Huang Ou, Pan Si-Jian, Li Yong

细胞生物学

发表日期：2025

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The N-type calcium channel rises from the ashes

N型钙通道从灰烬中崛起

期刊:Journal of Clinical Investigation

影响因子:13.6

doi:10.1172/JCI189308

Gandini, Maria A; Zamponi, Gerald W

发表日期：2025

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A pathological missense mutation in the deubiquitinase USP5 leads to insensitivity to pain.

去泛素化酶 USP5 中的致病性错义突变会导致痛觉丧失

期刊:Journal of Experimental Medicine

影响因子:10.6

doi:10.1084/jem.20241877

Antunes Flavia T T, Gandini Maria A, Garcia-Caballero Agustin, Huang Sun, Ali Md Yousof, Gambeta Eder, Souza Ivana A, Harding Erika K, Ferron Laurent, Stray-Pedersen Asbjorg, Gadotti Vinicius M, Zamponi Gerald W

发表日期：2025

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Biginelli dihydropyrimidines and their acetylated derivatives as L-/T-type calcium channel blockers: Synthesis, enantioseparation, and molecular modeling studies

Biginelli二氢嘧啶及其乙酰化衍生物作为L/T型钙通道阻滞剂：合成、对映体分离和分子建模研究

期刊:Archiv der Pharmazie

影响因子:3.6

doi:10.1002/ardp.202400584

Gündüz, Miyase Gözde; Dengiz, Cagatay; Denzinger, Katrin; Huang, Sun; Lee, J T; Nafie, Jordan W; Armstrong, Daniel W; Wolber, Gerhard; Zamponi, Gerald W

发表日期：2025

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Pharmacological inhibition of NaV1.8 by suzetrigine reveals potent analgesic potential without tolerance development in mice

苏泽曲林对NaV1.8的药理学抑制作用显示出强大的镇痛潜力，且在小鼠中未产生耐受性。

期刊:Molecular Brain

影响因子:2.9

doi:10.1186/s13041-025-01253-3

Ali, Md Yousof; Antunes, Flavia T T; Huang, Sun; Chen, Lina; Zamponi, Gerald W

发表日期：2025

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The terpenes alpha-bisabolol and camphene modulate pruritus via an action on Cav3.2 T-type calcium channels.

萜烯类化合物α-红没药醇和莰烯通过作用于Cav3.2 T型钙通道来调节瘙痒

期刊:Molecular Brain

影响因子:2.9

doi:10.1186/s13041-025-01196-9

Antunes Flavia T T, Gadotti Vinicius M, Zamponi Gerald W

发表日期：2025

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A tale of two calcium channels: structural pharmacology of Cav2.1 and Cav3.2

两种钙通道的故事：Cav2.1 和 Cav3.2 的结构药理学

期刊:Cell Research

影响因子:25.9

doi:10.1038/s41422-024-00961-0

Ferron, Laurent; Zamponi, Gerald W

发表日期：2024

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Opening the K(V)3.1 gates: A therapeutic strategy for progressive myoclonus epilepsy type 7?

打开K(V)3.1通道：治疗进行性肌阵挛性癫痫7型的一种策略？

期刊:Cell Reports Medicine

影响因子:10.6

doi:10.1016/j.xcrm.2024.101425

Gandini, Maria A; Zamponi, Gerald W

发表日期：2024

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Ca(V)3.2 T-type calcium channels contribute to CGRP- induced allodynia in a rodent model of experimental migraine

Ca(V)3.2 T型钙通道在啮齿动物实验性偏头痛模型中参与CGRP诱导的痛觉过敏

期刊:Journal of Headache and Pain

影响因子:7.9

doi:10.1186/s10194-024-01921-0

Baggio, Darciane F; Gambeta, Eder; Souza, Ivana A; Huang, Sun; Zamponi, Gerald W; Chichorro, Juliana G

发表日期：2024

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