Zhou Leqi相关文献与解析，生知库 | 链接生命科学的每一步

Xiang, Haoyi; Shen, Baining; Lao, Weifeng; Bai, Bingjun; Chen, Min; Zhou, Leqi; Yu, Guanyu; Zhang, Wei; Chen, Huan; Wang, Yuhao; Jiang, Hangjin; Song, Zhangfa

微生物学

肿瘤

肠癌

肿瘤免疫

发表日期：2026

文献求助收藏

Liquid biopsy in cancer drug resistance: real-time monitoring, mechanistic insights, and translational applications

液体活检在癌症耐药性研究中的应用：实时监测、机制解析和转化应用

期刊:Frontiers in Immunology

影响因子:5.9

doi:10.3389/fimmu.2026.1795789

Li, Yiyang; Liu, Zixuan; Yuan, Benliang; Zhang, Tianshuai; Zhu, Xiaoming; Zhou, Leqi; Zhang, Wei; Yu, Guanyu

Baicalin Augments 5-Fluorouracil Efficacy in Colorectal Cancer by Triggering MLKL-Dependent Necroptosis: A Novel Strategy to Overcome Chemoresistance

黄芩苷通过触发MLKL依赖性坏死性凋亡增强5-氟尿嘧啶在结直肠癌中的疗效：一种克服化疗耐药性的新策略

期刊:International Journal of Molecular Sciences

影响因子:4.9

doi:10.3390/ijms27062919

Yuan, Jingwen; Peng, Zhiying; Wen, Rongbo; Zhou, Leqi; Cao, Fuao; Zhang, Tianshuai; Wu, Yingjie; Wu, Jiayue; Lin, Ran; Yu, Guanyu; Zhang, Wei

Editorial: Advancements in solid tumor immunotherapy: enhancing efficacy and overcoming resistance

社论：实体瘤免疫疗法的进展：提高疗效并克服耐药性

期刊:Frontiers in Cell and Developmental Biology

影响因子:4.3

doi:10.3389/fcell.2026.1814863

Jiang, Yi; Wang, ShaoDong; Zhou, Leqi; Zhang, Tao; Feng, Haoran; Zhang, Tao

免疫/内分泌

发表日期：2026

文献求助收藏

ST6GAL1-Mediated Sialylation Stabilizes PD-L1 and Drives Immunosuppressive Tumor Microenvironment in Colorectal Cancer.

ST6GAL1 介导的唾液酸化可稳定 PD-L1 并驱动结直肠癌的免疫抑制性肿瘤微环境。

期刊:Advanced Science

影响因子:14.1

doi:10.1002/advs.202406225

Xu Ximo, Liu Jingyi, Qin Wei, Ding Chengsheng, Cai Zhenghao, Shu Duohuo, Zhong Hao, Hu Yanyan, Yu Mengqin, Zhou Leqi, Li Jianwen, Zheng Minhua, Li Bin, Zhang Sen, Yang Xiao, Feng Bo

KLF6-mediated recruitment of the p300 complex enhances H3K23su and cooperatively upregulates SEMA3C with FOSL2 to drive 5-FU resistance in colon cancer cells.

KLF6 介导的 p300 复合物募集增强 H3K23su，并与 FOSL2 协同上调 SEMA3C，从而驱动结肠癌细胞产生 5-FU 耐药性

期刊:Experimental and Molecular Medicine

影响因子:12.9

doi:10.1038/s12276-025-01424-1

Zhang Bishu, Qi Tuoya, Lin Jiewei, Zhai Shuyu, Wang Xuelong, Zhou Leqi, Deng Xiaxing

Safety and clinical efficacy of neoadjuvant chemoradiation therapy with immunotherapy for organ preservation in ultra-low rectal cancer: preliminary results of the CHOICE-I trial: a prospective cohort study

新辅助放化疗联合免疫疗法在超低位直肠癌器官保留治疗中的安全性和临床疗效：CHOICE-I试验的初步结果：一项前瞻性队列研究

期刊:International Journal of Surgery

影响因子:10.1

doi:10.1097/JS9.0000000000002225

Zhou, Leqi; Yu, Guanyu; Shen, Yuxin; Wen, Rongbo; Ding, Haibo; Zhou, Jidian; Zhu, Xiaoming; Hong, Yonggang; Gong, Haifeng; Liu, Lianjie; Wang, Hao; Zhang, Huojun; Bai, Chenguang; Hao, Liqiang; Zhang, Wei

hnRNP A1 inhibits colorectal cancer tumorigenesis and progression by regulating fatty acid metabolism and RNA stability.

hnRNP A1 通过调节脂肪酸代谢和 RNA 稳定性来抑制结直肠癌的肿瘤发生和进展。

期刊:Cell Death Discovery

影响因子:7

doi:10.1038/s41420-025-02814-0

Ji Kai, Zhou Leqi, Zhang Tianshuai, Fan Hao, Xie Gang, Man Wenjiang, Wang Can, Tian Yucheng, Chen Li, Wang Guimin, Liu Mulin, Zhu Bing, Zhang Wei, Yu Guanyu

Impact and potential value of immunosenescence on solid gastrointestinal tumors

免疫衰老对实体胃肠道肿瘤的影响及潜在价值

期刊:Frontiers in Immunology

影响因子:5.9

doi:10.3389/fimmu.2024.1375730

Zhang, Tianshuai; Wen, Rongbo; Fan, Hao; Yu, Yue; Jia, Hang; Peng, Zhiying; Zhou, Leqi; Yu, Guanyu; Zhang, Wei

New insight in immunotherapy and combine therapy in colorectal cancer

结直肠癌免疫疗法和联合疗法的新见解

期刊:Frontiers in Cell and Developmental Biology

影响因子:4.3

doi:10.3389/fcell.2024.1453630

Ji, Kai; Jia, Hang; Liu, Zixuan; Yu, Guanyu; Wen, Rongbo; Zhang, Tianshuai; Peng, Zhiying; Man, Wenjiang; Tian, Yucheng; Wang, Can; Ling, Qianlong; Zhang, Wei; Zhou, Leqi; Liu, Mulin; Zhu, Bing

The landscape of tissue-resident microbiota across normal, polyp, and colorectal cancer tissues

正常组织、息肉组织和结直肠癌组织中组织驻留微生物群落的分布情况

Liquid biopsy in cancer drug resistance: real-time monitoring, mechanistic insights, and translational applications

液体活检在癌症耐药性研究中的应用：实时监测、机制解析和转化应用

Baicalin Augments 5-Fluorouracil Efficacy in Colorectal Cancer by Triggering MLKL-Dependent Necroptosis: A Novel Strategy to Overcome Chemoresistance

黄芩苷通过触发MLKL依赖性坏死性凋亡增强5-氟尿嘧啶在结直肠癌中的疗效：一种克服化疗耐药性的新策略

Editorial: Advancements in solid tumor immunotherapy: enhancing efficacy and overcoming resistance

社论：实体瘤免疫疗法的进展：提高疗效并克服耐药性

ST6GAL1-Mediated Sialylation Stabilizes PD-L1 and Drives Immunosuppressive Tumor Microenvironment in Colorectal Cancer.

ST6GAL1 介导的唾液酸化可稳定 PD-L1 并驱动结直肠癌的免疫抑制性肿瘤微环境。

KLF6-mediated recruitment of the p300 complex enhances H3K23su and cooperatively upregulates SEMA3C with FOSL2 to drive 5-FU resistance in colon cancer cells.

KLF6 介导的 p300 复合物募集增强 H3K23su，并与 FOSL2 协同上调 SEMA3C，从而驱动结肠癌细胞产生 5-FU 耐药性

Safety and clinical efficacy of neoadjuvant chemoradiation therapy with immunotherapy for organ preservation in ultra-low rectal cancer: preliminary results of the CHOICE-I trial: a prospective cohort study

新辅助放化疗联合免疫疗法在超低位直肠癌器官保留治疗中的安全性和临床疗效：CHOICE-I试验的初步结果：一项前瞻性队列研究

hnRNP A1 inhibits colorectal cancer tumorigenesis and progression by regulating fatty acid metabolism and RNA stability.

hnRNP A1 通过调节脂肪酸代谢和 RNA 稳定性来抑制结直肠癌的肿瘤发生和进展。

Impact and potential value of immunosenescence on solid gastrointestinal tumors

免疫衰老对实体胃肠道肿瘤的影响及潜在价值

New insight in immunotherapy and combine therapy in colorectal cancer

结直肠癌免疫疗法和联合疗法的新见解