Human hypofunctional NCF1 variants promote pulmonary fibrosis in the bleomycin-induced mouse model and patients with systemic sclerosis via expansion of SPP1(+) monocytes-derived macrophages
人类低功能性 NCF1 变体通过 SPP1(+) 单核细胞衍生的巨噬细胞的扩增,促进博来霉素诱导的小鼠模型和系统性硬化症患者的肺纤维化。
期刊:Annals of the Rheumatic Diseases
影响因子:20.6
doi:10.1136/ard-2024-226034
Yuan, Xinran; Qin, Xiaodong; Takemoto, Kenji; Zhao, Jian; Sanderson, Matthew; Xu, Xue; Zhang, Yu; Helke, Kristi L; Jacobs Wolf, Bethany; Guthridge, Joel M; James, Judith A; Zhou, Xiaodong; Assassi, Shervin; Feghali-Bostwick, Carol; Wang, Dandan; Sun, Lingyun; Tsao, Betty P
巨噬细胞
巨噬细胞
Human
单核细胞
系统性硬化症
细胞生物学
免疫/内分泌