日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A Plastic EMP1+ to LGR5+ Cell State Conversion as a Bypass to KRASG12D Pharmacologic Inhibition in Metastatic Colorectal Cancer.

转移性结直肠癌中 EMP1+ 到 LGR5+ 细胞状态的转化可绕过 KRASG12D 药物抑制。

Centonze Alessia, Roura Adrià-Jaume, Novillo-Font Meritxell, Giordano Cristina, Hernando-Momblona Xavier, Llanses Montserrat, Prats Paula, Sevillano Marta, Cabot Débora, Novell Mireia, Pabst Gabriel, Andersch Florian, Cañellas-Socias AdriÃ, Zhang Chong, Giakoumakis Nikolaos-Nikiforos, Sparks Hugh, Dunsby Chris, Colombelli Julien, Fernández-Barral Asunción, Sancho Elena, Stephan-Otto Attolini Camille, Muñoz Alberto, Barbachano Antonio, Palmer Héctor G, Martínez-Quintanilla Jordi, Zuber Johannes, Blaj Cristina, Quintana Elsa, Cortina Carme, Marti-Renom Marc A, Batlle Eduard

A multivalent adaptor mechanism drives the nuclear import of proteasomes

多价衔接蛋白机制驱动蛋白酶体的核输入

Brunner, Hanna L; Kalis, Robert W; Grundmann, Lorenz; Hodáková, Zuzana; Koskova, Zuzana; Grishkovskaya, Irina; de Almeida, Melanie; Hinterndorfer, Matthias; Knaudt, Hannah; Höfflin, Simon; Andersch, Florian; Kotisch, Harald; Dickmanns, Achim; Cuylen-Haering, Sara; Zuber, Johannes; Haselbach, David

In vivo CRISPR/Cas9 screens identify new regulators of B cell activation and plasma cell differentiation.

体内 CRISPR/Cas9 筛选鉴定出 B 细胞活化和浆细胞分化的新调节因子。

Calderón Lesly, Schäfer Markus, Rončević Marina, Rauschmeier René, Jaritz Markus, Schwickert Tanja A, Sun Qiong, Pauli Andrea, Zuber Johannes, Busslinger Meinrad

Transcriptional and epigenetic rewiring by the NUP98::KDM5A fusion oncoprotein directly activates CDK12.

NUP98::KDM5A 融合癌蛋白通过转录和表观遗传重编程直接激活 CDK12

Troester Selina, Eder Thomas, Wukowits Nadja, Piontek Martin, Fernández-Pernas Pablo, Schmoellerl Johannes, Haladik Ben, Manhart Gabriele, Allram Melanie, Maurer-Granofszky Margarita, Scheidegger Nastassja, Nebral Karin, Superti-Furga Giulio, Meisel Roland, Bornhauser Beat, Valent Peter, Dworzak Michael N, Zuber Johannes, Boztug Kaan, Grebien Florian

mTORC1 cooperates with tRNA wobble modification to sustain the protein synthesis machinery.

mTORC1 与 tRNA 摆动修饰协同作用,以维持蛋白质合成机制

Hermann Julia, Borteçen Toman, Kalis Robert, Kowar Alexander, Pechincha Catarina, Vogt Vivien, Schneider Martin, Helm Dominic, Krijgsveld Jeroen, Loayza-Puch Fabricio, Zuber Johannes, Palm Wilhelm

Loss-of-function genetic screen unveils synergistic efficacy of PARG inhibition with combined 5-fluorouracil and irinotecan treatment in colorectal cancer.

功能缺失基因筛选揭示了 PARG 抑制剂与 5-氟尿嘧啶和伊立替康联合治疗在结直肠癌中的协同疗效。

Queralt Cristina, Moreta-Moraleda Cristina, Costa Marta, Grau-Leal Ferran, Diesch Jeannine, Vendrell-Ayats Carla, Musulén Eva, Wright Roni H G, Bugés Cristina, Manzano José Luis, Cabrero-de Las Heras Sara, Zuber Johannes, Buschbeck Marcus, Forcales Sonia-V, Martínez-Balibrea Eva

Engineered microRNA scaffolds for potent gene silencing in vivo.

工程化microRNA支架用于体内强效基因沉默

Militello Giuseppe, Greig Alyssa, Bi Chongfeng, Vasileva Ana, Zavodszky Maria I, Lo Shih-Ching, Guilmette Edward, Clarner Pete, Liu Bin, Bhat Guruharsha, Suh Junghae, Dow Lukas, Zuber Johannes, Fellmann Christof, Premsrirut Prem K

Cancer Evolution: A Multifaceted Affair

癌症演变:一个多方面的过程

Ciriello, Giovanni; Magnani, Luca; Aitken, Sarah J; Akkari, Leila; Behjati, Sam; Hanahan, Douglas; Landau, Dan A; Lopez-Bigas, Nuria; Lupiáñez, Darío G; Marine, Jean-Christophe; Martin-Villalba, Ana; Natoli, Gioacchino; Obenauf, Anna C; Oricchio, Elisa; Scaffidi, Paola; Sottoriva, Andrea; Swarbrick, Alexander; Tonon, Giovanni; Vanharanta, Sakari; Zuber, Johannes

Suppression of toxic transgene expression by optimized artificial miRNAs increases AAV vector yields in HEK-293 cells

通过优化人工miRNA抑制毒性转基因表达可提高HEK-293细胞中AAV载体的产量。

Blahetek, Gina; Mayer, Christine; Zuber, Johannes; Lenter, Martin; Strobel, Benjamin

MYC determines lineage commitment in KRAS-driven primary liver cancer development

MYC决定KRAS驱动的原发性肝癌发展过程中的谱系定向。

D'Artista, Luana; Moschopoulou, Athina Anastasia; Barozzi, Iros; Craig, Amanda J; Seehawer, Marco; Herrmann, Lea; Minnich, Martina; Kang, Tae-Won; Rist, Elke; Henning, Melanie; Klotz, Sabrina; Heinzmann, Florian; Harbig, Jule; Sipos, Bence; Longerich, Thomas; Eilers, Martin; Dauch, Daniel; Zuber, Johannes; Wang, Xin Wei; Zender, Lars