The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression
Sirt1激活剂SRT3025通过减少肝脏Pcsk9分泌和增强Ldlr表达,在Apoe-/-小鼠中发挥抗动脉粥样硬化作用。
期刊:European Heart Journal
影响因子:35.6
doi:10.1093/eurheartj/ehu095
Miranda, Melroy X; van Tits, Lambertus J; Lohmann, Christine; Arsiwala, Tasneem; Winnik, Stephan; Tailleux, Anne; Stein, Sokrates; Gomes, Ana P; Suri, Vipin; Ellis, James L; Lutz, Thomas A; Hottiger, Michael O; Sinclair, David A; Auwerx, Johan; Schoonjans, Kristina; Staels, Bart; Lüscher, Thomas F; Matter, Christian M