日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A broad kinase inhibitor library live cell imaging screen using liver, kidney and cardiac hiPSC-ICAM1-eGFP reporter lineages identifies liabilities for TNFα pathway modulation

利用肝脏、肾脏和心脏hiPSC-ICAM1-eGFP报告基因谱系进行广泛的激酶抑制剂库活细胞成像筛选,鉴定出TNFα通路调控的潜在靶点

Vlasveld, Matthijs; van den Berk, Linda; Piñero, Janet; Helmke, Palle S; Ecker, Gerhard F; van Rossom, Rob; Schmidt, Bela Z; Verfaillie, Catherine; Tassis, Konstantinos; Callegaro, Giulia; Bouwman, Peter; van de Water, Bob

Disrupting CDK9 activity suppresses triple-negative breast cancer and is enhanced by EGFR Inhibition

干扰 CDK9 活性可抑制三阴性乳腺癌,而 EGFR 抑制剂可增强这种抑制作用。

van der Noord, Vera E; McLaughlin, Ronan P; Karuntu, Jessica S; He, Jichao; Timmermans, A Mieke; Basnet, Sunita K C; Long, Yi; Diab, Sarah Al Haj; Tadesse, Solomon; Proost, Natalie; van Gerwen, Bastiaan; Siteur, Bjørn; van de Ven, Marieke; Pont, Chantal; Le Dévédec, Sylvia E; Martens, John W M; Wang, Shudong; Zhang, Yinghui; van de Water, Bob

Decoding SR protein regulation: kinases, phosphatases, and therapeutic targeting strategies

解码SR蛋白调控:激酶、磷酸酶和治疗靶向策略

Liu, Nasi; van der Ende, Fleur; van de Water, Bob; Le Dévédec, Sylvia E

Advancing transcriptomics-based mechanistic assessment of nephrotoxicity in vitro using the human RPTEC/TERT1 TXG-MAPr gene co-expression network

利用人 RPTEC/TERT1 TXG-MAPr 基因共表达网络推进基于转录组学的体外肾毒性机制评估

van Kessel, Hugo W; Kunnen, Steven J; Callegaro, Giulia; van de Water, Bob

ReCHEMbinant stapling enhances intracellular delivery and bioactivity of engineered protein inhibitors

ReCHEMbinant 交联技术可增强工程化蛋白抑制剂的细胞内递送和生物活性。

Kahler, Jan Pascal; Ellenbroek, Brecht D; van der Noord, Vera E; van de Water, Bob; Pomplun, Sebastian J

Cell type heterogeneity in gene co-expression networks: implications for toxicological research

基因共表达网络中的细胞类型异质性:对毒理学研究的启示

Bruns, Imke B; Li, Yingxue; Stevens, James L; van de Water, Bob; Callegaro, Giulia

Spatio-temporal transcriptomic analysis reveals distinct nephrotoxicity, DNA damage, and regeneration response after cisplatin

时空转录组分析揭示了顺铂治疗后不同的肾毒性、DNA损伤和再生反应

Wijaya, Lukas S; Kunnen, Steven J; Trairatphisan, Panuwat; Fisher, Ciarán P; Crosby, Meredith E; Schaefer, Kai; Bodié, Karen; Vaughan, Erin E; Breidenbach, Laura; Reich, Thomas; Clausznitzer, Diana; Bonnet, Sylvestre; Zheng, Sipeng; Pont, Chantal; Stevens, James L; Le Dévédec, Sylvia E; van de Water, Bob

Pharmacological CLK inhibition disrupts SR protein function and RNA splicing blocking cell growth and migration in TNBC.

药理学上的 CLK 抑制会破坏 SR 蛋白功能和 RNA 剪接,从而阻断 TNBC 中的细胞生长和迁移

Liu Nasi, van der Velde Jurjun J S, Ramdjielal Sherien, Koedoot Esmee, van Overbeek Nila K, Batenburg Daisy, Vertegaal Alfred C O, van de Water Bob, Le Dévédec Sylvia E

Utilizing rat kidney gene co-expression networks to enhance safety assessment biomarker identification and human translation

利用大鼠肾脏基因共表达网络增强安全性评估生物标志物的识别和人类转化

Kunnen, Steven J; Callegaro, Giulia; Sutherland, Jeffrey J; Trairatphisan, Panuwat; van Kessel, Hugo W; Wijaya, Lukas S; Chung, Git; Pye, Keith; Goldstein, Keith M; Teague, Claire R; Fisher, Ciaran P; Saez-Rodriguez, Julio; Brown, Colin; Elmore, Susan A; Heinz-Taheny, Kathleen M; Stevens, James L; van de Water, Bob

Computational modelling identifies primary mediators of crosstalk between DNA damage and oxidative stress responses

计算模型识别出DNA损伤和氧化应激反应之间相互作用的主要介质

Burgers, Elsje J; Sharma, Raju P; Eugenio, Carl Joshua S; Heldring, Muriel M; Wijaya, Lukas S; van de Water, Bob; Beltman, Joost B