日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

p53-dependent crosstalk between DNA replication integrity and redox metabolism mediated through a NRF2-PARP1 axis

通过NRF2-PARP1轴介导的p53依赖性DNA复制完整性与氧化还原代谢之间的串扰

Gamal Ahmed Elfar, Obed Aning, Tsz Wai Ngai, Pearlyn Yeo, Joel Wai Kit Chan, Shang Hong Sim, Leonard Goh, Ju Yuan, Cheryl Zi Jin Phua, Joanna Zhen Zhen Yeo, Shi Ya Mak, Brian Kim Poh Goh, Pierce Kah-Hoe Chow, Wai Leong Tam, Ying Swan Ho, Chit Fang Cheok

CSB and SMARCAL1 compete for RPA32 at stalled forks and differentially control the fate of stalled forks in BRCA2-deficient cells

CSB 和 SMARCAL1 竞争停滞叉处的 RPA32,并在 BRCA2 缺陷细胞中差异控制停滞叉的命运

Nicole L Batenburg, Dana J Sowa, John R Walker, Sara N Andres, Xu-Dong Zhu

Exploring the structural landscape of DNA maintenance proteins

探索 DNA 维护蛋白的结构景观

Kenneth Bødkter Schou, Samuel Mandacaru, Muhammad Tahir, Nikola Tom, Ann-Sofie Nilsson, Jens S Andersen, Matteo Tiberti, Elena Papaleo, Jiri Bartek

DSS1 restrains BRCA2's engagement with dsDNA for homologous recombination, replication fork protection, and R-loop homeostasis

DSS1 抑制 BRCA2 与 dsDNA 的结合,以实现同源重组、复制叉保护和 R 环稳态

Yuxin Huang #, Wenjing Li #, Tzeh Foo, Jae-Hoon Ji, Bo Wu, Nozomi Tomimatsu, Qingming Fang, Boya Gao, Melissa Long, Jingfei Xu, Rouf Maqbool, Bipasha Mukherjee, Tengyang Ni, Salvador Alejo, Yuan He, Sandeep Burma, Li Lan, Bing Xia, Weixing Zhao

Harnessing DNA replication stress to target RBM10 deficiency in lung adenocarcinoma

利用 DNA 复制压力来治疗肺腺癌中的 RBM10 缺陷

Feras E Machour, Enas R Abu-Zhayia, Joyce Kamar, Alma Sophia Barisaac, Itamar Simon, Nabieh Ayoub

HLTF disrupts Cas9-DNA post-cleavage complexes to allow DNA break processing

HLTF 破坏 Cas9-DNA 切割后复合物,从而实现 DNA 断裂处理

Giordano Reginato, Maria Rosaria Dello Stritto, Yanbo Wang, Jingzhou Hao, Raphael Pavani, Michael Schmitz, Swagata Halder, Vincent Morin, Elda Cannavo, Ilaria Ceppi, Stefan Braunshier, Ananya Acharya, Virginie Ropars, Jean-Baptiste Charbonnier, Martin Jinek, Andrè Nussenzweig, Taekjip Ha, Petr Cejka

MRE11 and TREX1 control senescence by coordinating replication stress and interferon signaling

MRE11 和 TREX1 通过协调复制压力和干扰素信号来控制衰老

Hervé Técher, Diyavarshini Gopaul, Jonathan Heuzé, Nail Bouzalmad, Baptiste Leray, Audrey Vernet, Clément Mettling, Jérôme Moreaux, Philippe Pasero, Yea-Lih Lin

Oncogenic c-Myc induces replication stress by increasing cohesins chromatin occupancy in a CTCF-dependent manner

致癌 c-Myc 以 CTCF 依赖的方式增加黏连蛋白染色质占有率,从而诱导复制压力

Silvia Peripolli, Leticia Meneguello, Chiara Perrod, Tanya Singh, Harshil Patel, Sazia T Rahman, Koshiro Kiso, Peter Thorpe, Vincenzo Calvanese, Cosetta Bertoli, Robertus A M de Bruin

The PARP1 selective inhibitor saruparib (AZD5305) elicits potent and durable antitumor activity in patient-derived BRCA1/2-associated cancer models

PARP1 选择性抑制剂 saruparib (AZD5305) 在患者来源的 BRCA1/2 相关癌症模型中表现出强效且持久的抗肿瘤活性

Andrea Herencia-Ropero, Alba Llop-Guevara, Anna D Staniszewska, Joanna Domènech-Vivó, Eduardo García-Galea, Alejandro Moles-Fernández, Flaminia Pedretti, Heura Domènech, Olga Rodríguez, Marta Guzmán, Enrique J Arenas, Helena Verdaguer, Fernando J Calero-Nieto, Sara Talbot, Luis Tobalina, Elisabetta

The GATAD2B-NuRD complex drives DNA:RNA hybrid-dependent chromatin boundary formation upon DNA damage

DNA 损伤后,GATAD2B-NuRD 复合物驱动 DNA:RNA 杂交依赖性染色质边界的形成

Zhichao Liu, Kamal Ajit, Yupei Wu, Wei-Guo Zhu, Monika Gullerova