用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | HeLa cells, HepG2 cells, HEK-293 cells, MCF-7 cells, Ramos cells |
| Positive IHC-Autostainer detected in | human tonsil tissue, human stomach cancer tissue, human liver cancer tissue, human breast cancer tissue, human tonsillitis tissue, human appendicitis tissue |
| Positive IHC detected in | human tonsillitis tissue, human skin cancer tissue, Human Spleen tissue, Human renal cancer, human malignant melanoma tissue, human prostate cancer tissue, human Breast cancer tissue, human liver tissue, human stomach cancer tissue, human pancreas cancer tissue, human appendicitis tissue, human liver cancer tissue, Cholangiocarcinoma tissue, human osteosarcoma tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF-P detected in | human lung cancer tissue, human thyroid cancer tissue |
| Positive IF/ICC detected in | HeLa cells, MCF-7 cells, U2OS cells, HepG2 cells, A431 cells, A549 cells |
推荐稀释比例
- Western Blot (WB)1:5000-1:50000
- Immunohistochemistry (IHC)-AUTOSTAINER1:500-1:2000
- Immunohistochemistry (IHC)1:1000-1:4000
- Immunofluorescence (IF)-P1:50-1:500
- Immunofluorescence (IF)/ICC1:200-1:800
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
The Ki-67 protein (also known as MKI67) is a cellular marker for proliferation. Ki67 is present during all active phases of the cell cycle (G1, S, G2 and M), but is absent in resting cells (G0). Cellular content of Ki-67 protein markedly increases during cell progression through S phase of the cell cycle. Therefore, the nuclear expression of Ki67 can be evaluated to assess tumor proliferation by immunohistochemistry. It has been demonstrated to be of prognostic value in breast cancer. In head and neck cancer, several studies have reported an association between high proliferative activity and poorer prognosis.
文献引用 (14)
IFITM2 Modulates Endocytosis Maintaining Neural Stem Cells in Developing Neocortex.
IFITM2 调节内吞作用，维持发育中新皮层的神经干细胞
SLC16A3 as an immunosuppressive Kupffer cell marker predicts poor prognosis in HBV-positive hepatocellular carcinoma.
SLC16A3 作为免疫抑制性库普弗细胞标志物，可预测 HBV 阳性肝细胞癌的不良预后
LncRNA HOXB-AS4 Promotes Tumor Malignant Phenotype in Head and Neck Squamous Cell Carcinoma and Serves as a Prognosis Marker.
LncRNA HOXB-AS4 促进头颈部鳞状细胞癌的肿瘤恶性表型，并可作为预后标志物
Expression of S100β during mouse cochlear development.
小鼠耳蜗发育过程中S100β的表达
Mechanics-activated fibroblasts promote pulmonary group 2 innate lymphoid cell plasticity propelling silicosis progression
机械激活的成纤维细胞促进肺部2型固有淋巴细胞的可塑性，从而加速矽肺病的进展。
WNT4 promotes the symmetric fission of crypt in radiation-induced intestinal epithelial regeneration
WNT4 促进辐射诱导肠上皮再生中隐窝对称裂变
Deciphering the pathogenic role of rare RAF1 heterozygous missense mutation in the late-presenting DDH
揭示罕见 RAF1 杂合错义突变在晚期 DDH 中的致病作用
Carrageenan maintains the contractile phenotype of vascular smooth muscle cells by increasing macromolecular crowding in vitro
角叉菜胶通过增加体外大分子拥挤来维持血管平滑肌细胞的收缩表型
Developmental expression of calretinin in the mouse cochlea
小鼠耳蜗中钙结合蛋白的发育表达
Synaptopodin-2 Isoforms Have Specific Binding Partners and Display Distinct, Muscle Cell Type-Specific Expression Patterns
Synaptopodin-2 同工型具有特异性结合伙伴，并显示出独特的、肌肉细胞类型特异性的表达模式
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