用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | NTERA-2 cl.D1 cells |
| Positive IF/ICC detected in | human embronic stem cells |
| Positive FC (Intra) detected in | NCCIT cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
Nanog is a member of the homeobox family of DNA binding transcription factors and has been shown to maintain embryonic stem (ES) cell self-renewal independently of leukemia inhibitory factor (LIF)/Stat3. Nanog mRNA is present in pluripotent mouse and human cell lines, and absent from differentiated cells. Functionally, Nanog works together with other key pluripotent factors (Oct4, Sox2, and Lin28) to reprogram human fibroblasts and generate induced pluripotent stem (iPS) cells. These key factors form a regulatory network to support or limit each other's expression level, which maintains the properties of ES cells. Affinity purified rabbit anti-Nanog can be used to demonstrate pluripotency of ES and IPS cells. There are two kinds of variants that can be recognized by NANOG, one is a normal form (~39 kDa), the other is a post-translation modified form (~48 kDa) (21136380 ). Nanog has two isoforms with molecular weights of 34.4 kDa and 31.9 kDa. (PMID: 21969378)
文献引用 (78)
A novel pathway for stemness propagation and chemoresistance in non-small cell lung cancer via phosphorylated PKM2-loaded small extracellular vesicles.
通过磷酸化PKM2负载的小细胞外囊泡，在非小细胞肺癌中实现干性增殖和化疗耐药性的新途径
ERCC6L-mediated stabilization of HIF-1α enhances glycolysis and stemness properties of lung adenocarcinoma cells.
ERCC6L介导的HIF-1α稳定作用增强了肺腺癌细胞的糖酵解和干性
Molecule interacting with CasL-2 enhances tumor progression and alters radiosensitivity in cervical cancer.
与 CasL-2 相互作用的分子可促进肿瘤进展并改变宫颈癌的放射敏感性
TC2N maintains stem cell-like characteristics to accelerate lung carcinogenesis by blockade of dual specificity protein phosphatase 3
TC2N 保持干细胞样特性，通过阻断双特异性蛋白磷酸酶 3 来加速肺癌的发生
Synergistic role of miRNA-1811 and miRNA-302 in enhancing direct reprogramming efficiency of chicken embryo fibroblasts to induced pluripotent stem cells.
miRNA-1811 和 miRNA-302 在增强鸡胚成纤维细胞直接重编程为诱导多能干细胞的效率方面发挥协同作用
Deuterium-depleted water inhibits the malignant progression of colorectal cancer cells by modulating oxidative stress.
氘耗竭水通过调节氧化应激抑制结直肠癌细胞的恶性进展
Development of a 3D-3 co-culture microbead consisting of cancer-associated fibroblasts and human umbilical vein endothelial cells for the anti-tumor drug assessment of lung cancer.
开发由癌症相关成纤维细胞和人脐静脉内皮细胞组成的 3D-3 共培养微珠，用于肺癌抗肿瘤药物评估
Generation and characterization of three induced pluripotent stem cell lines for modeling coronary artery vasospasm.
构建和表征三种诱导多能干细胞系，用于模拟冠状动脉血管痉挛
CMYC-initiated HNF1A-AS1 overexpression maintains the stemness of gastric cancer cells
CMYC 启动的 HNF1A-AS1 过表达维持胃癌细胞的干细胞性
Genome-wide mapping of native co-localized G4s and R-loops in living cells
活细胞中天然共定位 G4 和 R 环的全基因组映射
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