CPT1A Polyclonal antibody (15184-1-AP)
Carnitine O-palmitoyltransferase 1; liver isoform; Carnitine O-palmitoyltransferase I; CPT I; CPT1; CPT-1A
用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | HeLa cells, A549 cells, HepG2 cells, MCF-7 cells, mouse liver tissue, rat liver tissue, mouse spleen tissue |
| Positive IP detected in | HepG2 cells |
| Positive IHC detected in | human liver cancer tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF/ICC detected in | HeLa cells, HepG2 cells |
| Positive FC (Intra) detected in | HeLa cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
CPT1A, also named CPT1, CPT1-L and L-CPTI, belongs to the carnitine/choline acetyltransferase family. CPT1A gene is localized Chromosome 11q13.1-2. Carnitine palmitoyltransferase (CPT) deficiencies are common disorders of mitochondrial fatty acid oxidation. The CPT system is made up of two separate proteins located in the outer (CPT1) and inner (CPT2) mitochondrial membranes. CPT1A is an active form of related liver-type carnitine palmitoyltransferase I (PMID: 11001805). CPT1A deficiency presents as recurrent attacks of fasting hypoketotic hypoglycemia. (PMID: 15363638). This antibody can bind the close sequences genes.
文献引用 (157)
Alterations in PD-L1 succinylation shape anti-tumor immune responses in melanoma.
PD-L1琥珀酰化改变影响黑色素瘤的抗肿瘤免疫反应
Early-life exercise extends healthspan but not lifespan in mice.
早期运动可以延长小鼠的健康寿命，但不能延长其寿命
Moderate-intensity interval exercise exacerbates cardiac lipotoxicity in high-fat, high-calories diet-fed mice
中等强度间歇运动加剧高脂肪、高热量饮食小鼠的心脏脂毒性
Targeting Histone Deacetylase 11 with a Highly Selective Inhibitor for the Treatment of MASLD.
利用高选择性抑制剂靶向组蛋白去乙酰化酶 11 治疗 MASLD
Inhibiting FAT1 Blocks Metabolic Bypass to Enhance Antitumor Efficacy of TCA Cycle Inhibition through Suppressing CPT1A-Dependent Fatty Acid Oxidation.
抑制 FAT1 可阻断代谢旁路，通过抑制 CPT1A 依赖性脂肪酸氧化来增强 TCA 循环抑制剂的抗肿瘤功效
Asprosin-FABP5 Interaction Modulates Mitochondrial Fatty Acid Oxidation through PPARα Contributing to MASLD Development.
Asprosin-FABP5 相互作用通过 PPARα 调节线粒体脂肪酸氧化，从而促进 MASLD 的发展
LncRNA Gm35585 transcriptionally activates the peroxidase EHHADH against diet-induced fatty liver.
LncRNA Gm35585 转录激活过氧化物酶 EHHADH 以对抗饮食诱导的脂肪肝
PRMT1-mediated methylation of UBE2m promoting calcium oxalate crystal-induced kidney injury by inhibiting fatty acid metabolism.
PRMT1介导的UBE2m甲基化通过抑制脂肪酸代谢促进草酸钙晶体引起的肾损伤
Anthraquinones of Cassiae Semen alleviate lipid accumulation in obesity by regulating brown adipose tissue and liver function.
决明子中的蒽醌类化合物通过调节棕色脂肪组织和肝脏功能来缓解肥胖中的脂质积累
Membrane-associated ring-CH-type finger 2 protects against metabolic dysfunction-associated fatty liver disease by targeting fatty acid synthase.
膜相关环状 CH 型指状蛋白 2 通过靶向脂肪酸合成酶来防止代谢功能障碍相关的脂肪肝疾病
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