MMP2 Polyclonal antibody (10373-2-AP)
72 kDa gelatinase; 72 kDa type IV collagenase; CLG4A; EC:3.4.24.24; Gelatinase A
用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | HT-1080 cells, MCF-7 cells, U-87 MG cells, HepG2 cells, U-251 cells, J774A.1 cells |
| Positive IP detected in | MCF-7 cells |
| Positive IHC detected in | human gliomas tissue, human placenta tissue, human prostate cancer tissue, human heart tissue, human oesophagus tissue, human breast cancer tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF-P detected in | human placenta tissue |
| Positive IF/ICC detected in | HepG2 cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
MMP2, also named as CLG4A, Gelatinase Am, TBE-1 and PEX, belongs to the peptidase M10A family. It is ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. MMP2 contributes to myocardial oxidative stress by regulating the activity of GSK3beta. It cleaves GSK3beta in vitro. MMP2 can be cleaved into PEX chain(~60kd). Western blot analysis showed that the 72 kDa and 62/65 kDa proteinase activities were pro-MMP2 and the active enzyme, respectively (PMID:11112697,PMID: 30867536).
文献引用 (292)
Microenvironment-driven transformable self-assembly nanoplatform enables spatiotemporal remodeling for rheumatoid arthritis therapy.
微环境驱动的可变形自组装纳米平台实现了类风湿性关节炎治疗的时空重塑
HSF2 drives breast cancer progression by acting as a stage-specific switch between proliferation and invasion.
HSF2 通过作为增殖和侵袭之间的阶段特异性开关来驱动乳腺癌的进展
Calcium dysregulation disrupts mitochondrial homeostasis by interfering AMPK/Drp1 pathway to aggravate plaque progression and instability
钙稳态失衡会干扰 AMPK/Drp1 通路，从而破坏线粒体稳态，加剧斑块进展和不稳定性。
Targeting PIM1 by Bruceine D attenuates skin fibrosis via myofibroblast ferroptosis
布鲁辛D靶向PIM1可通过诱导肌成纤维细胞铁死亡来减轻皮肤纤维化。
Cationic microbubble loading hSIRT3 and hTIMP3 optimize cardiac-targeted delivery and myocardial protection in the porcine MI/R model.
阳离子微泡负载 hSIRT3 和 hTIMP3 可优化猪 MI/R 模型中的心脏靶向递送和心肌保护
Targeting LINC02320 prevents colorectal cancer growth via GRB7-dependent inhibition of MAPK signaling pathway.
靶向 LINC02320 可通过 GRB7 依赖性抑制 MAPK 信号通路来阻止结直肠癌的生长
GPX3 promotes cisplatin resistance in TNBC by manipulating ROS-TGFB1-ZEB2.
GPX3 通过操纵 ROS-TGFB1-ZEB2 促进 TNBC 对顺铂的耐药性
Genetic and pharmacological targeting of Snail inhibits atherosclerosis by relieving intraplaque endothelium dysfunction and associated inflammation.
通过基因和药物靶向 Snail 可缓解斑块内皮功能障碍和相关炎症，从而抑制动脉粥样硬化
CILP1 interacting with YBX1 promotes hypertrophic scar formation by suppressing PPARs transcription
CILP1与YBX1相互作用，通过抑制PPARs转录促进肥厚性瘢痕形成。
Intermediate filament IFFO1 negatively regulates the migration of lung cancer cells by inhibiting the IQGAP3-Cdc42 interaction
中间丝蛋白IFFO1通过抑制IQGAP3-Cdc42相互作用，负调控肺癌细胞的迁移。
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