用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | HEK-293 cells, HeLa cells, HepG2 cells, SH-SY5Y cells, mouse liver tissue, rat liver tissue |
| Positive IP detected in | mouse liver tissue |
| Positive IHC detected in | human breast cancer tissue, mouse brain tissue, mouse brown adipose tissue, rat brown adipose tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF/ICC detected in | HeLa cells |
| Positive FC (Intra) detected in | HeLa cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
FASN gene codes for an enzyme essential for de novo fatty acid synthesis and cellular substrate energy metabolism. Active FASN is a homodimer in which each peptide subunit has a molecular weight of 260 kDa. FASN is overexpressed in various types of cancer including glioblastomas and is a potential therapeutic target. Recently FASN has been reported to contribute to the neurogenesis since FASN mutation caused intellectual disability in mice.
文献引用 (97)
Lipogenic enzyme FASN promotes mutant p53 accumulation and gain-of-function through palmitoylation
脂肪生成酶 FASN 通过棕榈酰化促进突变 p53 积累和功能获得
LIMA1 O-GlcNAcylation Promotes Hepatic Lipid Deposition through Inducing β-catenin-Regulated FASn Expression in Metabolic Dysfunction-Associated Steatotic Liver Disease.
LIMA1 O-GlcNAc糖基化通过诱导β-catenin调节的FASN表达促进代谢功能障碍相关脂肪肝疾病中的肝脏脂质沉积
Accumulation of Damaging Lipids in the Arf1-Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia.
Arf1 缺失神经元中有害脂质的积累通过释放 mtDNA 和激活小胶质细胞中的炎症通路促进神经退行性变
IGF2BP3/ESM1/KLF10/BECN1 positive feedback loop: a novel therapeutic target in ovarian cancer via lipid metabolism reprogramming.
IGF2BP3/ESM1/KLF10/BECN1 正反馈环路：通过脂质代谢重编程治疗卵巢癌的新靶点
Matrix stiffness boosts PDAC chemoresistance via SCD1-dependent lipid metabolic reprogramming.
基质硬度通过 SCD1 依赖性脂质代谢重编程增强 PDAC 的化疗耐药性
Lipin1-dependent transcriptional inactivation of SREBPs contributes to selinexor sensitivity in multiple myeloma
Lipin1依赖的SREBP转录失活导致多发性骨髓瘤对selinexor敏感
Baicalin mitigates alcoholic-associated liver disease via SOCS1-driven reprogramming of macrophages.
黄芩苷通过SOCS1驱动的巨噬细胞重编程来缓解酒精性肝病
Senkyunolide I suppresses hepatic stellate cell activation and liver fibrosis by reprogramming VDR-dependent fatty acid metabolism.
Senkyunolide I 通过重编程 VDR 依赖性脂肪酸代谢来抑制肝星状细胞活化和肝纤维化
Hsp90α promotes lipogenesis by stabilizing FASN and promoting FASN transcription via LXRα in hepatocellular carcinoma
Hsp90α 通过稳定 FASN 并通过 LXRα 促进肝细胞癌中的 FASN 转录来促进脂肪生成
Small molecule-driven LKB1 deacetylation is responsible for the inhibition of hepatic lipid response in NAFLD
小分子驱动的 LKB1 去乙酰化负责抑制 NAFLD 中的肝脏脂质反应
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