Cytochrome c Polyclonal antibody (10993-1-AP)
CYC; CYCS
用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | HeLa cells, mouse skeletal muscle tissue, rat skeletal muscle tissue, NIH/3T3 cells, rat liver tissue, HEK-293 cells, HepG2 cells, C2C12 cells, Jurkat cells, mouse kidney tissue, rat kidney tissue |
| Positive IHC detected in | human liver tissue, human breast cancer tissue, human colon cancer tissue, mouse brain tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF-P detected in | mouse eye tissue |
| Positive FC (Intra) detected in | HepG2 cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
Cytochrome c is a 12-15 kDa electron transporting protein located in the inner mitochondrial membrane. As a part of respiratory chain, cytochrome c plays a critical role in the process of oxidative phosphorylation and ATP producing. Besides, cytochrome c also gets implicated in apoptosis process. Upon apoptotic stimulation, cytochrome c ca99n be released from mitochondria into cytoplasm, which is required for caspase-3 activation and the occurrence of apoptosis.
文献引用 (155)
Deacetylation of ANXA2 by SIRT2 desensitizes hepatocellular carcinoma cells to donafenib via promoting protective autophagy.
SIRT2 对 ANXA2 的去乙酰化作用通过促进保护性自噬，使肝细胞癌细胞对多那非尼脱敏
Melatonin receptor 1a alleviates sleep fragmentation-aggravated testicular injury in T2DM by suppression of TAB1/TAK1 complex through FGFR1.
褪黑激素受体 1a 通过 FGFR1 抑制 TAB1/TAK1 复合物，从而减轻 2 型糖尿病患者因睡眠碎片化而加重的睾丸损伤
Icaritin Represses Autophagy to Promote Colorectal Cancer Cell Apoptosis and Sensitized Low-Temperature Photothermal Therapy via Targeting HSP90-TXNDC9 Interactions.
淫羊藿苷通过靶向 HSP90-TXNDC9 相互作用抑制自噬，促进结直肠癌细胞凋亡并增强低温光热疗法的敏感性
MRPL13 enhances mitochondrial function and promotes tumor progression in ovarian cancer by inhibiting mPTP opening via SLC25A6.
MRPL13 通过 SLC25A6 抑制 mPTP 开放，从而增强线粒体功能并促进卵巢癌的肿瘤进展
CHCHD2 rescues the mitochondrial dysfunction in iPSC-derived neurons from patient with Mohr-Tranebjaerg syndrome
CHCHD2 挽救了 Mohr-Tranebjaerg 综合征患者 iPSC 衍生神经元中的线粒体功能障碍
Aβ -induced excessive mitochondrial fission drives type H blood vessels injury to aggravate bone loss in APP/PS1 mice with Alzheimer's diseases
Aβ 诱导的线粒体过度裂变导致 H 型血管损伤加剧阿尔茨海默病 APP/PS1 小鼠的骨质流失
Piezo1 promotes intervertebral disc degeneration through the Ca(2+)/F-actin/Yap signaling axis.
Piezo1 通过 Ca(2+)/F-肌动蛋白/Yap 信号轴促进椎间盘退变
Prepubertal Diabetes Stagnates Testicular Development by Skewing Autophagy Homeostasis in Leydig Cells.
青春期前糖尿病通过扰乱睾丸间质细胞的自噬稳态来阻碍睾丸发育
Targeted spiral ganglion neuron degeneration in parvalbumin-Cre neonatal mice.
小白蛋白-Cre新生小鼠的靶向螺旋神经节神经元退化
Sarsasapogenin protects hair cells from cisplatin-induced ototoxicity by attenuating apoptosis and ferroptosis via alleviating oxidative stress
菝葜皂苷元通过减轻氧化应激，减弱细胞凋亡和铁死亡，从而保护毛细胞免受顺铂诱导的耳毒性损伤。
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