ERK1/2 Polyclonal antibody (11257-1-AP)
ERK; ERK1; ERK2; EC:2.7.11.24; ERK-1
用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | PC-12 cells, HEK-293 cells, HeLa cells, NIH/3T3 cells, C6 cells, mouse brain tissue, mouse lung tissue |
| Positive IP detected in | HEK-293 cells |
| Positive IHC detected in | human colon cancer tissue, human breast cancer tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF/ICC detected in | HEK-293 cells |
| Positive FC (Intra) detected in | HeLa cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
ERK1 and ERK2 belongs to the protein kinase superfamily. It is involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. ERK1/2 catalized the reaction: ATP + a protein = ADP + a phosphoprotein. It is activated by tyrosine phosphorylation in response to INS and NGF. This antibody can recognize both ERK1 and ERK2 with the molecular mass of 38-44 kDa.
文献引用 (139)
Chimeric antigen receptor with novel intracellular modules improves antitumor performance of T cells
具有新型胞内模块的嵌合抗原受体可提高T细胞的抗肿瘤活性
Rewiring of 3D chromatin topology orchestrates transcriptional reprogramming in muscle fiber-type specification and transformation
三维染色质拓扑结构的重塑调控着肌肉纤维类型分化和转化过程中的转录重编程。
Phosphorylation of POU3F3 Mediated Nuclear Translocation Promotes Proliferation in Non-Small Cell Lung Cancer through Accelerating ATP5PF Transcription and ATP Production.
POU3F3 的磷酸化介导的核转位通过加速 ATP5PF 转录和 ATP 生成促进非小细胞肺癌的增殖
Integrated stress response activation induced by usnic acid alleviates BCL-2 inhibitor ABT-199 resistance in acute myeloid leukemia.
松萝酸诱导的整合应激反应激活可缓解急性髓系白血病中 BCL-2 抑制剂 ABT-199 的耐药性
Non-canonical activation of MAPK signaling by the lncRNA ASH1L-AS1-encoded microprotein APPLE through inhibition of PP1/PP2A-mediated ERK1/2 dephosphorylation in hepatocellular carcinoma.
lncRNA ASH1L-AS1 编码的微蛋白 APPLE 通过抑制 PP1/PP2A 介导的 ERK1/2 去磷酸化，在肝细胞癌中非经典地激活 MAPK 信号通路
Delivery of an ERK inhibitor using bioactive lipid nanoparticles reduces angiogenesis and prevents oral squamous cell carcinoma development.
利用生物活性脂质纳米颗粒递送 ERK 抑制剂可减少血管生成并预防口腔鳞状细胞癌的发生
FNDC5/irisin-enriched sEVs conjugated with bone-targeting aptamer alleviate osteoporosis: a potential alternative to exercise.
富含 FNDC5/irisin 的 sEV 与骨靶向适体结合可缓解骨质疏松症：一种潜在的运动替代方案
A CD147-targeted small-molecule inhibitor potentiates gemcitabine efficacy by triggering ferroptosis in pancreatic ductal adenocarcinoma
CD147靶向小分子抑制剂通过诱导胰腺导管腺癌中的铁死亡来增强吉西他滨的疗效
KRASG12D-driven pentose phosphate pathway remodeling imparts a targetable vulnerability synergizing with MRTX1133 for durable remissions in PDAC
KRASG12D 驱动的戊糖磷酸途径重塑赋予可靶向的脆弱性，与 MRTX1133 协同作用，实现 PDAC 的持久缓解
H3K18 lactylation-mediated nucleotide-binding oligomerization domain-2 (NOD2) expression promotes bilirubin-induced pyroptosis of astrocytes.
H3K18 乳酸化介导的核苷酸结合寡聚化结构域 2 (NOD2) 表达促进胆红素诱导的星形胶质细胞焦亡
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