CD31 Polyclonal antibody (11265-1-AP)
EndoCAM; GPIIA; GPIIA'; PECA1; PECAM 1
用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | HUVEC cells, human peripheral blood platelets, Jurkat cells, THP-1 cells |
| Positive IP detected in | Jurkat cells |
| Positive IHC detected in | human liver cancer tissue, human tonsillitis tissue, human placenta tissue, human renal cell carcinoma tissue, human hepatocirrhosis tissue, human kidney tissue, human gliomas tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF-P detected in | human endometrial cancer tissue, human tonsillitis tissue |
| Positive IF/ICC detected in | HUVEC cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
Platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) is a member of the immunoglobulin gene superfamily of cell adhesion molecules. CD31 is a transmembrane glycoprotein that is highly expressed on the surface of the endothelium, making up a large portion of its intracellular junctions. PECAM-1 is also present on the surface of hematopoietic cells and immune cells including platelets, monocytes, neutrophils, natural killer cells, megakaryocytes and some types of T-cell (PMID: 9011572). As well as its role in cell-cell adhesion, PECAM-1 functions as a signaling receptor, and is involved in important physiological events such as nitric oxide production, regulation of T-cell immunity and tolerance, leukocyte transendothelial migration and inflammation and angiogenesis (PMID: 21183735; 20978210; 17872453; 20634489).
文献引用 (142)
Single-cell sequencing reveals the role of IL-33 (+) endothelial subsets in promoting early gastric cancer progression.
单细胞测序揭示了IL-33（+）内皮细胞亚群在促进早期胃癌进展中的作用
All-in-one extracellular matrix-based powders with instant self-assembly and multiple bioactivities integrate hemostasis and in-situ tissue functional repair.
具有即时自组装和多种生物活性的全效细胞外基质粉末，整合了止血和原位组织功能修复功能
Microenvironment-feedback regulated hydrogels as living wound healing materials.
微环境反馈调控水凝胶作为活体伤口愈合材料
USP25 ameliorates vascular remodeling by deubiquitinating FOXO3 and promoting autophagic degradation of FOXO3
USP25通过去除FOXO3的泛素化并促进FOXO3的自噬降解来改善血管重塑。
Endothelial AGGF1 promotes retinal angiogenesis by coordinating TNFSF12/FN14 signalling
内皮细胞 AGGF1 通过协调 TNFSF12/FN14 信号传导促进视网膜血管生成
CXCL13 Damages Blood Spinal Cord Barrier by Promoting RNF6/Sqstm1-Ubiquitination Induced Autophagy in Experimental Allergic Encephalomyelitis.
CXCL13 通过促进 RNF6/Sqstm1 泛素化诱导的自噬来破坏实验性过敏性脑脊髓炎中的血脊髓屏障
Calpain-2-Mediated Endothelial Focal Adhesion Disruption in Thoracic Aortic Dissection.
钙蛋白酶-2介导的内皮细胞局灶性粘附破坏在胸主动脉夹层中的作用
Nanosilicates promote angiogenesis through activation of ROS-mediated WNT/β-catenin pathway.
纳米硅酸盐通过激活 ROS 介导的 WNT/β-catenin 通路促进血管生成
Phytochemical nanozymes reprogram redox for balanced antimicrobial and regenerative therapy in acute and chronic diabetic wounds.
植物化学纳米酶可重编程氧化还原状态，从而在急性和慢性糖尿病伤口中实现平衡的抗菌和再生治疗
Lemon-derived nanoparticle-functionalized hydrogels regulate macrophage reprogramming to promote diabetic wound healing
柠檬衍生的纳米颗粒功能化水凝胶通过调节巨噬细胞重编程促进糖尿病伤口愈合
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