NQO1 Polyclonal antibody (11451-1-AP)
Azoreductase; DHQU; DIA 4; DIA4; DT diaphorase
用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | HepG2 cells, K-562 cells, LNCaP cells, MCF-7 cells |
| Positive IP detected in | HepG2 cells |
| Positive IHC detected in | human colon cancer tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF/ICC detected in | HepG2 cells |
| Positive FC (Intra) detected in | MCF-7 cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
NQO1, also named as DIA4, NMOR1, DTD and QR1, belongs to the NAD(P)H dehydrogenase (quinone) family. This enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. It is known to be involved in benzene metabolism. In human studies of ozone exposure, polymorphisms in oxidative stress genes (NQO1, GSTM1, GSTP1) modify respiratory symptoms, lung function, biomarkers and risk of asthma. (PMID:18511640; 18848868 ) This antibody recognizes all the three isoforms (26-27 kDa and 31 kDa) of NQO1 and the homo-dimer form (66-70 kDa) of NQO1.
文献引用 (104)
The prostacyclin receptor PTGIR is a NRF2-dependent regulator of CD8+ T cell exhaustion
前列环素受体PTGIR是NRF2依赖性的CD8+ T细胞耗竭调节因子。
Redox-Induced Stabilization of AMBRA1 by USP7 Promotes Intestinal Oxidative Stress and Colitis Through Antagonizing DUB3-Mediated NRF2 Deubiquitination.
USP7 通过氧化还原诱导稳定 AMBRA1，从而拮抗 DUB3 介导的 NRF2 去泛素化，促进肠道氧化应激和结肠炎
Dipyridamole Acts as Clinical Ferroptosis Inhibitor to Prevent from Tissue Injury.
双嘧达莫作为临床铁死亡抑制剂，可防止组织损伤
DNA damage response pathway regulates Nrf2 in response to oxidative stress.
DNA损伤反应通路通过调节Nrf2来应对氧化应激
PPM1D is directly degraded by proteasomes in a ubiquitination-independent manner through its carboxyl-terminal region.
PPM1D 通过其羧基末端区域以不依赖于泛素化的方式被蛋白酶体直接降解
MOTS-c attenuates lung ischemia-reperfusion injury via MYH9-Dependent nuclear translocation and transcriptional activation of antioxidant genes.
MOTS-c 通过 MYH9 依赖的核转位和抗氧化基因的转录激活来减轻肺缺血再灌注损伤
Pectin-Zein-IPA nanoparticles promote functional recovery and alleviate neuroinflammation after spinal cord injury
果胶-玉米醇溶蛋白-异丙醇纳米粒子促进脊髓损伤后功能恢复并减轻神经炎症
Endothelial Gsα deficiency promotes ferroptosis and exacerbates atherosclerosis in apolipoprotein E-deficient mice via the inhibition of NRF2 signaling.
内皮细胞 Gsα 缺乏通过抑制 NRF2 信号传导促进载脂蛋白 E 缺乏小鼠的铁死亡并加剧动脉粥样硬化
Enhanced prevention on postoperative atrial fibrillation by using anti-inflammatory biodegradable drug patch.
使用抗炎可降解药物贴剂加强预防术后房颤
The CD163â+âtissue-infiltrating macrophages regulate ferroptosis in thyroid-associated ophthalmopathy orbital fibroblasts via the TGF-β/Smad2/3 signaling pathway.
CD163+组织浸润巨噬细胞通过TGF-β/Smad2/3信号通路调节甲状腺相关眼病眼眶成纤维细胞的铁死亡
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