GRP78/BIP Polyclonal antibody (11587-1-AP)
BIP; GRP78; HSPA5; 78 kDa glucose-regulated protein; Binding-immunoglobulin protein
用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | BxPC-3 cells, Caco-2 cells, HEK-293 cells, HeLa cells, HepG2 cells, mouse brain tissue, mouse liver tissue, rat brain tissue, rat liver tissue, HT-29 cells |
| Positive IP detected in | MCF-7 cells |
| Positive IHC detected in | human pancreas cancer tissue, human breast cancer tissue, mouse kidney tissue, rat brain tissue, mouse heart tissue, human colon cancer tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF/ICC detected in | HepG2 cells, Thapsigargin treated HepG2 cells |
| Positive FC (Intra) detected in | HeLa cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
GRP78 (HSPA5), also referred to as 'immunoglobulin heavy chain-binding protein' (BiP), is a member of the heat-shock protein-70 (HSP70) family and is involved in the folding and assembly of proteins in the endoplasmic reticulum (ER). It is a constitutively expressed resident protein of the ER in all eukaryotic cells. Recently it has been reported that GRP78 is associated with apoptosis or inhibition of cancer cell growth. 11587-1-AP antibody recognizes one or two bands with MW 70-78 kDa for the signal peptide of GRP78 protein can be finally cleaved.
文献引用 (233)
Pathology-oriented multiplexing enables integrative disease mapping
以病理学为导向的多重分析能够实现疾病的整合映射。
Targeting ceramide transfer protein sensitizes AML to FLT3 inhibitors via a GRP78-ATF6-CHOP axis
通过 GRP78-ATF6-CHOP 轴靶向神经酰胺转移蛋白增强 AML 对 FLT3 抑制剂的敏感性
Hypoxia Induced Lnc191 Upregulation Dictates the Progression of Esophageal Squamous Cell Carcinoma by Activating GRP78/ERK Pathway.
缺氧诱导的 Lnc191 上调通过激活 GRP78/ERK 通路决定食管鳞状细胞癌的进展
GRP78 Nanobody-Directed Immunotoxin Activates Innate Immunity Through STING Pathway to Synergize Tumor Immunotherapy.
GRP78纳米抗体导向免疫毒素通过STING通路激活先天免疫，从而增强肿瘤免疫疗法的疗效
Targeting the self-amplifying loop between ATF6 and SNAI1 to inhibit epithelialâmesenchymal transition in fibrotic lesions.
靶向 ATF6 和 SNAI1 之间的自我放大环路，以抑制纤维化病变中的上皮-间质转化
HBV Precore G1896A Mutation Promotes Malignancy of Hepatocellular Carcinoma by Activating Endoplasmic Reticulum Stress to Enhance Aerobic Glycolysis.
HBV 前核心 G1896A 突变通过激活内质网应激增强有氧糖酵解，促进肝细胞癌的恶性进展
Quercetin-loaded exosomes delivery system prevents myopia progression by targeting endoplasmic reticulum stress and ferroptosis in scleral fibroblasts.
槲皮素负载的外泌体递送系统通过靶向巩膜成纤维细胞中的内质网应激和铁死亡来阻止近视进展
SREBF1 mediates immunoparalysis of dendritic cells in sepsis by regulating lipid metabolism and endoplasmic reticulum stress.
SREBF1 通过调节脂质代谢和内质网应激介导脓毒症中树突状细胞的免疫麻痹
The selenocysteine-containing protein SELENOT maintains dopamine signaling in the midbrain to protect mice from hyperactivity disorder.
含硒半胱氨酸的蛋白质 SELENOT 维持中脑中的多巴胺信号传导，从而保护小鼠免受多动症的侵害
FKBP10 Promotes the Muscle Invasion of Bladder Cancer via Lamin A Dysregulation
FKBP10通过层蛋白A失调促进膀胱癌的肌肉侵袭
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