用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | ROS1728 cells, MCF-7 cells |
| Positive IHC detected in | rat skin tissue, rat kidney tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF/ICC detected in | ROS1728 cells |
| Positive FC (Intra) detected in | HepG2 cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
RUNX2, also named as AML3, CBFA1, OSF2 and PEBP2A, is a Transcription factor which involved in osteoblastic differentiation and skeletal morphogenesis. It is essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters By similarity. RUNX2 inhibits MYST4-dependent transcriptional activation. The antibody is specific to RUNX2.
文献引用 (67)
Targeted Delivery of α-ketoglutarate to Macrophages in Bone: A Novel Therapeutic Strategy for Improving Fracture Healing in Type 2 Diabetes.
将α-酮戊二酸靶向递送至骨骼中的巨噬细胞：一种改善2型糖尿病骨折愈合的新型治疗策略
Multiomic identification of senescent stem cell populations critical for osteoarthritis progression and therapy in subchondral bones.
软骨下骨中衰老干细胞群的多组学鉴定，这些细胞群对骨关节炎的进展和治疗至关重要
A novel strategy for bone defect repair: Stromal cell-derived factor 1α sustained-release acellular fish scale scaffolds combined with injection of bone marrow mesenchymal stem cells promote bone regeneration.
一种新的骨缺损修复策略：基质细胞衍生因子 1α 缓释无细胞鱼鳞支架结合骨髓间充质干细胞注射促进骨再生
Synergistic exacerbation of periprosthetic osteolysis by inflammatory bowel disease and titanium ions: Impaired osteogenesis of BMSCs via PI3K/AKT signaling.
炎症性肠病和钛离子协同加剧假体周围骨溶解：通过 PI3K/AKT 信号通路损害 BMSC 的成骨作用
Harnessing engineered exosomes as METTL3 carriers: Enhancing osteogenesis and suppressing lipogenesis in bone marrow mesenchymal stem cells for postmenopausal osteoporosis treatment
利用工程化外泌体作为METTL3载体：增强骨髓间充质干细胞的成骨作用并抑制脂肪生成，用于治疗绝经后骨质疏松症
CBD-conjugated BMP-inhibiting exosomes on collagen scaffold dual-target Achilles tendon repair: Synergistic regeneration and heterotopic ossification prevention
CBD偶联的BMP抑制外泌体在胶原支架上实现双靶向跟腱修复：协同促进再生并预防异位骨化
Functionalized Periosteum-Derived Microsphere-Hydrogel with Sequential Release of E7 Short Peptide/miR217 for Large Bone Defect Repairing
功能化骨膜衍生微球水凝胶连续释放E7短肽/miR217用于大骨缺损修复
YTHDF3 regulates IL32 mRNA stability to promote osteogenic differentiation of bone mesenchymal stem cells in ankylosing spondylitis.
YTHDF3 调节 IL32 mRNA 的稳定性，从而促进强直性脊柱炎中骨髓间充质干细胞的成骨分化
Ionizing radiation-mediated dendritic cell maturation exacerbates inflammatory response of bone marrow mesenchymal stem cells and impairs osteogenesis in radiation-induced jaw injury
电离辐射介导的树突状细胞成熟会加剧骨髓间充质干细胞的炎症反应，并损害放射性颌骨损伤中的成骨作用。
Piezo1 exacerbates inflammation-induced cartilaginous endplate degeneration by activating mitochondrial fission via the Ca(2+)/CaMKII/Drp1 axis.
Piezo1 通过 Ca(2+)/CaMKII/Drp1 轴激活线粒体分裂，加剧炎症引起的软骨终板退化
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