用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | HL-60 cells |
| Positive IP detected in | HL-60 cells |
| Positive IHC detected in | human colon cancer tissue, human liver tissue, human spleen tissue, rat spleen tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF-P detected in | human tonsillitis tissue |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
The MPO gene encodes myeloperoxidase, a lysosomal hemoprotein located in the azurophilic granules of polymorphonuclear (PMN) leukocytes and monocytes. In response to stimulation, MPO is activated into a transient intermediate with potent antimicrobial oxidizing abilities(PMID:17650507). The mRNA is translated into a single protein of 90 kDa, which displays enzymatic activity and undergoes proteolytic maturation into a heavy chain of 59 kDa and a light chain of 13.5 kDa; these subunits then dimerize into the mature tetramer and the mature MPO is a heterotetramer composed of two identical heavy chains and two identical light chains(PMID:12773517). Fragments with molecular masses of 43-47 kDa were formed by autocatalysis during warming in sample buffer (PMID:12960244). The 24-kDa material had a map identical to that of 13.5 kDa subunit and represents a dimer of the 13.5 kDa subunit (PMID:3008892). Defects in MPO are the cause of myeloperoxidase deficiency (MPOD). It has 3 isoforms produced by alternative splicing. This antibody is specific to MPO.
文献引用 (86)
Identifying fibroblast-derived sFRP2 as a therapeutic target and engineering siRNA therapy for uterine scarring.
确定成纤维细胞衍生的 sFRP2 作为治疗靶点，并设计 siRNA 疗法治疗子宫瘢痕
Cancer Cell-Secreted miR-33a Reduces Stress Granule Formation by Targeting Polyamine Metabolism in Stroma to Promote Tumourigenesis.
癌细胞分泌的 miR-33a 通过靶向基质中的多胺代谢来减少应激颗粒的形成，从而促进肿瘤发生
Sequential carbonyl derivatives and hydrazone adduct formation on myeloperoxidase contribute to development of ANCA vasculitis.
髓过氧化物酶上羰基衍生物和腙加合物的连续形成促进了 ANCA 血管炎的发展
Lactiplantibacillus plantarum -derived extracellular vesicles alleviate acute lung injury by inhibiting ferroptosis of macrophages.
植物乳杆菌衍生的细胞外囊泡通过抑制巨噬细胞的铁死亡来减轻急性肺损伤
Ascorbic acid deficiency promotes metabolic remodeling and pulmonary fibrosis that leads to respiratory failure in Sod1 and Akr1a double-knockout mice.
抗坏血酸缺乏会促进代谢重塑和肺纤维化，从而导致 Sod1 和 Akr1a 双敲除小鼠出现呼吸衰竭
Silicate-based therapy for inflammatory dilated cardiomyopathy by inhibiting the vicious cycle of immune inflammation via FOXO signaling
通过FOXO信号通路抑制免疫炎症的恶性循环，利用硅酸盐治疗炎症性扩张型心肌病
Dysregulation of gut microbiota stimulates NETs-driven HCC intrahepatic metastasis: therapeutic implications of healthy faecal microbiota transplantation.
肠道菌群失调刺激NETs驱动的HCC肝内转移：健康粪便菌群移植的治疗意义
Bifunctional chemokine-nanobody fusion protein enhances neutrophil recruitment to impede Acanthamoeba immune evasion.
双功能趋化因子-纳米抗体融合蛋白增强中性粒细胞募集，从而阻碍棘阿米巴的免疫逃逸
EMAP-II from macrophage-derived extracellular vesicles drives neutrophil extracellular traps formation via PI3K/AKT/mtROS in lung ischemia/reperfusion injury
巨噬细胞来源的细胞外囊泡产生的 EMAP-II 通过 PI3K/AKT/mtROS 通路驱动肺缺血/再灌注损伤中的中性粒细胞胞外陷阱形成。
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