Collagen Type III (N-terminal) Polyclonal antibody (22734-1-AP)
COL3; COL3A1; Collagen alpha 1(III) chain; Collagen alpha-1(III) chain; Collagen Type III
用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | mouse skin tissue, rat skin tissue |
| Positive IP detected in | mouse skin tissue |
| Positive IHC detected in | human hepatocirrhosis tissue, human pancreas cancer tissue, mouse liver tissue, mouse kidney tissue, human colon tissue, human skin cancer tissue, mouse heart tissue, mouse colon tissue, human skin tissue, human malignant melanoma tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF-P detected in | human colon tissue |
| Positive IF-Fro detected in | mouse colon tissue |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
Type III collagen is a fibrillar forming collagen comprising three α1(III) chains and is expressed in early embryos and throughout embryogenesis (PMID: 9050868). In the adult, type III collagen is a major component of the extracellular matrix in a variety of internal organs and skin. It occurs in most soft connective tissues along with type I collagen (PMID: 2445760). COL3A1 gene encodes type III procollagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms (PMID: 10706896; 2243125; 18389341). This antibody raised against 24-152 aa of prepro α1 (III) chain of human type III procollagen detects type III procollagen at 140-180 kDa and also in some lysates reveals a 70-kDa band which has been reported and may represent a cleaved form of type III procollagen (PMID: 17424834; 19648160; 22802960).
文献引用 (200)
Identifying fibroblast-derived sFRP2 as a therapeutic target and engineering siRNA therapy for uterine scarring.
确定成纤维细胞衍生的 sFRP2 作为治疗靶点，并设计 siRNA 疗法治疗子宫瘢痕
Keratinocyte-driven dermal collagen formation in the axolotl skin
蝾螈皮肤中角质形成细胞驱动的真皮胶原蛋白形成
Targeting the E Prostanoid Receptor EP4 Mitigates Cardiac Fibrosis Induced by β-Adrenergic Activation.
靶向 E 前列腺素受体 EP4 可减轻 β-肾上腺素能激活引起的心脏纤维化
From Invaginating Site to Deep Lesion: Spatial Transcriptomics Unravels Ectopic Endometrial Penetration Features in Adenomyosis.
从内陷部位到深部病变：空间转录组学揭示子宫腺肌症中异位子宫内膜浸润的特征
LIMA1 O-GlcNAcylation Promotes Hepatic Lipid Deposition through Inducing β-catenin-Regulated FASn Expression in Metabolic Dysfunction-Associated Steatotic Liver Disease.
LIMA1 O-GlcNAc糖基化通过诱导β-catenin调节的FASN表达促进代谢功能障碍相关脂肪肝疾病中的肝脏脂质沉积
Enhancing Tendon Regeneration: Investigating the Impact of Topography on the Secretome of Adipose-Derived Stem Cells.
增强肌腱再生：研究地形对脂肪干细胞分泌组的影响
Single-cell RNA sequencing reveals that myeloid S100A8/A9 is a novel regulator of the transition from adaptive hypertrophy to heart failure after pressure overload.
单细胞 RNA 测序显示，髓系 S100A8/A9 是压力超负荷后从适应性肥大到心力衰竭转变的新型调节因子
Early assessment and treatment of ventricular remodeling in vivo via a targeted ultrasonic molecular probe loaded with oxygen and cholecystokinin.
利用载有氧气和胆囊收缩素的靶向超声分子探针，对体内心室重构进行早期评估和治疗
PPDPF preserves integrity of proximal tubule by modulating NMNAT activity in chronic kidney diseases.
PPDPF 通过调节 NMNAT 活性来维持慢性肾脏疾病中近端肾小管的完整性
HSF2 drives breast cancer progression by acting as a stage-specific switch between proliferation and invasion.
HSF2 通过作为增殖和侵袭之间的阶段特异性开关来驱动乳腺癌的进展
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