Caspase 1/P20 Polyclonal antibody (22915-1-AP)
CASP1; Caspase1; CASP 1; CASP-1; Caspase 1
用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | Raji cells, HepG2 cells, THP-1 cells, U-937 cells |
| Positive IHC detected in | human spleen tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF/ICC detected in | / HUVEC cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
CASP1(caspase-1) is also named as IL1BC, IL1BCE and belongs to the peptidase C14A family. It is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta (IL1B), IL18, and IL33 precursor proteins. The active caspase-1 can increase cellular membrane permeability and intracellular calcium levels, which facilitates lysosome exocytosis and release of host antimicrobial factors and microbial products (PMID:21804020). It has 5 isoforms produced by alternative splicing. 22915-1-AP can recognize p45 procaspase and the mature fragment p20.
文献引用 (350)
Signal-induced NLRP3 phase separation initiates inflammasome activation.
信号诱导的NLRP3相分离启动炎症小体激活
Mast cells boost anti-tumor potency of MAIT cells via inflammasome-dependent secretion of IL-18
肥大细胞通过炎症小体依赖性分泌IL-18增强MAIT细胞的抗肿瘤效力
Accumulation of Damaging Lipids in the Arf1-Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia.
Arf1 缺失神经元中有害脂质的积累通过释放 mtDNA 和激活小胶质细胞中的炎症通路促进神经退行性变
Clemastine fumarate accelerates accumulation of disability in progressive multiple sclerosis by enhancing pyroptosis.
富马酸克莱马斯汀通过增强细胞焦亡加速进行性多发性硬化症患者的残疾程度
The m6A modification of SOX18 leads to increased PTX3 and cardiomyocyte pyroptosis in sepsis-induced cardiomyopathy.
SOX18 的 m6A 修饰导致脓毒症诱发的心肌病中 PTX3 增加和心肌细胞焦亡
Lysosomal zinc nanomodulation blocks macrophage pyroptosis for counteracting atherosclerosis progression.
溶酶体锌纳米调控阻断巨噬细胞焦亡，从而对抗动脉粥样硬化的进展
CD44 is a macrophage receptor for TcdB from Clostridioides difficile that via its lysine-158 succinylation contributes to inflammation
CD44是巨噬细胞上艰难梭菌TcdB的受体，其赖氨酸158琥珀酰化修饰可促进炎症反应。
Anemoside B4 alleviates ulcerative colitis by attenuating intestinal oxidative stress and NLRP3 inflammasome via activating aryl hydrocarbon receptor through remodeling the gut microbiome and metabolites.
Anemoside B4 通过重塑肠道微生物群和代谢物，激活芳烃受体，从而减轻肠道氧化应激和 NLRP3 炎症小体，进而缓解溃疡性结肠炎
Isoquercitrin mitigates intestinal ischemia-reperfusion injury by regulating intestinal flora and inhibiting NLRP3 inflammasome activation.
异槲皮苷通过调节肠道菌群和抑制 NLRP3 炎症小体活化来减轻肠道缺血再灌注损伤
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