NLRP3 Polyclonal antibody (19771-1-AP)
Angiotensin/vasopressin receptor AII/AVP-like; C1orf7; CIAS1; Cold-induced autoinflammatory syndrome 1 protein; EC:3.6.4.-
用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | THP-1 cells, Raji cells, LPS treated THP-1 cells |
| Positive IP detected in | THP-1 cells |
| Positive IF/ICC detected in | RAW 264.7 cells, HepG2 cells |
| Positive FC (Intra) detected in | THP-1 cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
NALP3, also named C1orf7, CIAS1, and PYPAF1, belongs to the NLRP family. NLRP3, a key and eponymous component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. NALP3 may function as an inducer of apoptosis. It interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling.NALP3 inhibits TNF-alpha-induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. NALP3 activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1) which is also known as familial cold urticaria. Defects in NLRP3 are a cause of Muckle-Wells syndrome (MWS) which is urticaria-deafness-amyloidosis syndrome. Defects in NLRP3 are the cause of chronic infantile neurologic cutaneous and articular syndrome (CINCA) which is also known as neonatal onset multisystem inflammatory disease (NOMID). The antibody recognizes the C-term of NALP3.
文献引用 (184)
Viral expression of NE/PPE enhances anti-colorectal cancer efficacy of oncolytic adenovirus by promoting TAM M1 polarization to reverse insufficient effector memory/effector CD8(+) T cell infiltration.
NE/PPE 的病毒表达通过促进 TAM M1 极化来逆转效应记忆/效应 CD8(+) T 细胞浸润不足，从而增强溶瘤腺病毒的抗结直肠癌疗效
Drug-free hyaluronic acid-microneedle with unexpected inhibition activity on benzalkonium chloride-induced corneal inflammation and stromal scarring.
不含药物的透明质酸微针对苯扎氯铵引起的角膜炎症和基质瘢痕具有意想不到的抑制活性
Exploring vestibulocerebellum-vestibular nuclei-spinal trigeminal nucleus causals communication and TRPV2 ion channel in a mouse model of vestibular migraine
探索前庭性偏头痛小鼠模型中的前庭小脑-前庭核-脊髓三叉神经核因果通讯和 TRPV2 离子通道
Emodin-Enhanced hUC-MSC extracellular vesicles alleviate acute pancreatitis by targeting inflammation and pyroptosis
大黄素增强的hUC-MSC细胞外囊泡通过靶向炎症和细胞焦亡来缓解急性胰腺炎
Formononetin ameliorates depression-like behaviors through rebalancing microglia M1/M2 polarization and inhibiting NLRP3 inflammasome: involvement of activating PPARα-mediated autophagy.
芒柄花素通过重新平衡小胶质细胞 M1/M2 极化和抑制 NLRP3 炎症小体来改善抑郁样行为：涉及激活 PPARα 介导的自噬
Sinomenine alleviates neuroinflammation in chronic cerebral hypoperfusion by promoting M2 microglial polarization and inhibiting neuronal pyroptosis via exosomal miRNA-223-3p
青藤碱通过促进M2型小胶质细胞极化和抑制神经元焦亡（通过外泌体miRNA-223-3p介导），从而减轻慢性脑低灌注引起的神经炎症。
The non-structural protein of SFTSV activates NLRP1 and CARD8 inflammasome through disrupting the DPP9-mediated ternary complex
SFTSV的非结构蛋白通过破坏DPP9介导的三元复合物来激活NLRP1和CARD8炎症小体。
Tetramethylpyrazine alleviates acute pancreatitis inflammation by inhibiting pyroptosis via the NRF2 pathway
四甲基吡嗪通过NRF2通路抑制细胞焦亡，从而减轻急性胰腺炎的炎症反应。
KAE ameliorates LPS-mediated acute lung injury by inhibiting PANoptosis through the intracellular DNA-cGAS-STING axis
KAE 通过细胞内 DNA-cGAS-STING 轴抑制 PANoptosis 来改善 LPS 介导的急性肺损伤
p16INK4a Deletion Alleviated Obesity-Associated Kidney Fibrosis by Regulating Metabolic Reprogramming and the Inflammasome Pathway.
p16INK4a 缺失通过调节代谢重编程和炎症小体通路缓解肥胖相关的肾纤维化
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