Caspase 3/P17/P19 Monoclonal antibody (66470-2-Ig)
CASP3; Caspase3; CASP 3; CASP-3
用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | Jurkat cells, HEK-293 cells, NIH/3T3 cells, HepG2 cells, HeLa cells |
| Positive IHC detected in | human breast cancer tissue, mouse liver tissue, mouse kidney tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF/ICC detected in | HepG2 cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
Caspases, a family of endoproteases, are critical players in cell regulatory networks controlling inflammation and cell death. Initiator caspases (caspase-2, -8, -9, -10, -11, and -12) cleave and activate downstream effector caspases (caspase-3, -6, and -7), which in turn execute apoptosis by cleaving targeted cellular proteins. Caspase 3 (also named CPP32, SCA-1, and Apopain) proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at the beginning of apoptosis. Caspase 3 plays a key role in the activation of sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Caspase 3 can also form heterocomplex with other proteins and performs the molecular mass of 50-70 kDa. This antibody can recognize p17, p19 and p32 of Caspase 3.
文献引用 (115)
A simple polydopamine-based platform for engineering extracellular vesicles with brain-targeting peptide and imaging probes to improve stroke outcome
一种基于聚多巴胺的简单平台，用于利用脑靶向肽和成像探针设计细胞外囊泡以改善中风结果
Early assessment and treatment of ventricular remodeling in vivo via a targeted ultrasonic molecular probe loaded with oxygen and cholecystokinin.
利用载有氧气和胆囊收缩素的靶向超声分子探针，对体内心室重构进行早期评估和治疗
A dual-targeting bio-liposomes nanodrug repair endothelial cell dysfunction and restore macrophage cholesterol flow homeostasis to treat early atherosclerosis.
双靶向生物脂质体纳米药物修复内皮细胞功能障碍并恢复巨噬细胞胆固醇流动稳态，以治疗早期动脉粥样硬化
Cationic microbubble loading hSIRT3 and hTIMP3 optimize cardiac-targeted delivery and myocardial protection in the porcine MI/R model.
阳离子微泡负载 hSIRT3 和 hTIMP3 可优化猪 MI/R 模型中的心脏靶向递送和心肌保护
S100A9 as a potential novel target for experimental autoimmune cystitis and interstitial cystitis/bladder pain syndrome
S100A9 作为实验性自身免疫性膀胱炎和间质性膀胱炎/膀胱疼痛综合征的潜在新靶点
Two-in-one: multifunctional poloxamer hydrogel accelerates endometrial regeneration and fertility restoration through synergistic regulation of KGF-2 and NO.
二合一：多功能泊洛沙姆水凝胶通过协同调节 KGF-2 和 NO 来加速子宫内膜再生和生育力恢复
hUC-MSCs and derived exosomes attenuate DEX-induced muscle atrophy through modulation of estrogen signaling pathway.
hUC-MSCs及其衍生的外泌体通过调节雌激素信号通路来减轻DEX诱导的肌肉萎缩
c-FLIP Protects Cardiac Microcirculation in Sepsis-Induced Myocardial Dysfunction Via FUNDC1-Mediated Regulation of Mitochondrial Autophagy.
c-FLIP 通过 FUNDC1 介导的线粒体自噬调节来保护脓毒症诱发的心肌功能障碍中的心脏微循环
Leonurine Attenuates CCl(4)-Induced Hepatic Fibrosis in Mice via the Hippo-YAP Pathway.
益母草碱通过 Hippo-YAP 通路减轻 CCl(4) 诱导的小鼠肝纤维化
Baicalein ameliorates cognitive decline induced by chronic cerebral hypoperfusion through the SIRT1-mediated Notch1 pathway to improve angiogenesis and suppress neuroinflammation.
黄芩苷通过 SIRT1 介导的 Notch1 通路改善血管生成并抑制神经炎症，从而改善慢性脑低灌注引起的认知衰退
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