Anti-Integrin beta 1 antibody [12G10] (Ab30394)

Product Specifications Anti-Integrin beta 1 antibody [12G10] (ab30394) is a mouse monoclonal antibody and is validated for use in Flow Cyt and ICC/IF in human samples. Anti-Integrin beta 1 antibody [12G10] (ab30394) specifically detects Integrin beta 1 (UniProt ID: P05556; Molecular weight: 86kDa) and is sold in 100 µg selling sizes. Quality and Validation Abcam's high quality validation processes ensure Anti-Integrin beta 1 antibody [12G10] (ab30394) has high sensitivity and specificity. The specificity of Anti-Integrin beta 1 antibody [12G10] (ab30394) has been confirmed by testing in knockout samples. Anti-Integrin beta 1 antibody [12G10] (ab30394) has been cited over 109 times in peer reviewed journals and is trusted by the scientific community. Anti-Integrin beta 1 antibody [12G10] (ab30394) has 7 independent reviews from customers. Related Products Conjugation-ready, carrier free format available for antibody clone 12G10 - ab230291. Antibody clone 12G10 is also available pre-conjugated to a variety of labels for your convenience - FITC, Alexa Fluor® 488, Alexa Fluor® 647 ( ab150002, ab202641, ab202643 ). This monoclonal antibody to integrin beta 1 has been knockout validated in ICC/IF and flow cytometry. The expected signal was observed in wild type cells and was not seen in knockout cells. The 12G10 monoclonal has been shown to increase ligand binding and enhances α5β1 integrin-fibronectin interactions (PubMed ID: 7537221). The antibody promotes cell attachment and spreading when binding to α5β1 integrin but inhibits these processes when binding to α4β1 integrin (PubMed ID: 15632175). Want a custom formulation? This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com