Maternal and neonatal vitamin D status, genotype and childhood celiac disease

孕产妇和新生儿维生素 D 状况、基因型与儿童乳糜泻

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作者:Karl Mårild, German Tapia, Margareta Haugen, Sandra R Dahl, Arieh S Cohen, Marika Lundqvist, Benedicte A Lie, Lars C Stene, Ketil Størdal

Background

Low concentration of 25-hydroxyvitamin D during pregnancy may be associated with offspring autoimmune disorders. Little is known about environmental triggers except gluten for celiac disease, a common immune-mediated disorder where seasonality of birth has been reported as a risk factor. We therefore aimed to test whether low maternal and neonatal 25-hydroxyvitamin D predicted higher risk of childhood celiac disease.

Conclusions

We found no support for the hypothesis that maternal or neonatal vitamin D status is related to the risk of childhood celiac disease.

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