Cross-talk between SOX2 and TGFβ Signaling Regulates EGFR-TKI Tolerance and Lung Cancer Dissemination

SOX2 和 TGFβ 信号之间的相互作用调节 EGFR-TKI 耐受性和肺癌扩散

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作者:Ming-Han Kuo #, An-Chun Lee #, Shih-Hsin Hsiao #, Sey-En Lin, Yu-Fan Chiu, Li-Hao Yang, Chia-Cherng Yu, Shih-Hwa Chiou, Hsien-Neng Huang, Jen-Chung Ko, Yu-Ting Chou

Significance

These findings suggest the potential of SOX2 as a prognostic marker in EGFR-mutant lung cancer, as SOX2-mediated cell plasticity regulated by TGFβ stimulation and epigenetic control affects EGFR-TKI tolerance and cancer dissemination.

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