TCR/CD3 activation and co-stimulation combined in one T cell retargeting system improve anti-tumor immunity

TCR/CD3激活和共刺激相结合的T细胞重定向系统可增强抗肿瘤免疫力

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Abstract

We have recently described a novel modular targeting platform for T cell recruitment that not only efficiently replaces but also is superior to conventional T cell-engaging bispecific antibodies as it allows for the flexible targeting of several antigens and the delivery of co-stimulatory ligands to malignant lesions, thereby enhancing the antitumor potential of redirected T cells.

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