Abstract
This article highlights the scientific achievements and professional career of William M. Pardridge, who passed away on 18th of June 2024. He was born in 1947 in Bethesda, Maryland, USA. William, known affectionately as Bill, was one of the most influential researchers in the blood-brain barrier (BBB) field. Bill’s research contributions to the field spun over 6 decades at the University of California, Los Angeles, and it was focused on the molecular physiology of the BBB, including the carrier-mediated transport of nutrients and small molecule drugs, the receptor-mediated transport of peptides and molecular Trojan horses, gene therapy of the brain with Trojan horse liposomes, and BBB genomics and proteomics. He founded ArmaGen Inc. in 2004, a biotech company that provided the basis for the treatment of CNS disorders with the molecular Trojan horse technology. This technology continues to be widely used in academia and in the biotech industry. He has been a cherished friend and mentor to many within the BBB community.