Abstract
We recently reported the radiosynthesis and in vitro evaluation of [(18)F]-2-(4-bromo-2,5-dimethoxyphenyl)-N-(2-(2-fluoroethoxy)benzyl)ethanamine, ([(18)F]FECIMBI-36) or ([(18)F]1), an agonist radioligand for 5HT(2A/2C) receptors in postmortem samples of human brain. Herein we describe the in vivo evaluation of [(18)F]FECIMBI-36 in vervet/African green monkeys by PET imaging. PET images show that [(18)F]FECIMBI-36 penetrates the blood-brain barrier and a low retention of radioactivity is observed in monkey brain. Although the time activity curves indicate a somehow heterogeneous distribution of the radioligand in the brain, the low level of [(18)F]FECIMBI-36 in brain may limit the use of this tracer for quantification of 5-HT(2A/2C) receptors by PET.